Activation of transposable elements during aging and neuronal decline in Drosophila

We report the surprising finding that several transposable elements are highly active in Drosophila brain during normal aging. We also show that mutations in Drosophila Argonaute 2 (dAgo2) exhibit exacerbated transposon expression in brain, progressive and age-dependent memory impairment and shorten...

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Bibliographic Details
Main Authors: Li, W., Prazak, L., Chatterjee, N., GrĂ¼ninger, S, Krug, L., Theodorou, D., Dubnau, J.
Format: Online
Language:English
Published: 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3821974/