Cognitive Functions across the GNB3 C825T Polymorphism in an Elderly Italian Population

To verify whether the C825T polymorphism of the GNB3 influences the response to neuropsychological tests, mini-mental state examination, digit span (DS), immediate and delayed prose memory, memory with interference at 10 and 30 seconds (MI 10 and 30), trail making tests (TMTs) A and B, abstraction t...

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Main Authors:	Casiglia, Edoardo, Giordano, Nunzia, Tikhonoff, Valérie, Boschetti, Giovanni, Mazza, Alberto, Caffi, Sandro, Guidotti, Federica, Bisiacchi, Patrizia
Format:	Online
Language:	English
Published:	Hindawi Publishing Corporation 2013
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3819753/

id	pubmed-3819753
recordtype	oai_dc
spelling	pubmed-38197532013-11-18 Cognitive Functions across the GNB3 C825T Polymorphism in an Elderly Italian Population Casiglia, Edoardo Giordano, Nunzia Tikhonoff, Valérie Boschetti, Giovanni Mazza, Alberto Caffi, Sandro Guidotti, Federica Bisiacchi, Patrizia Research Article To verify whether the C825T polymorphism of the GNB3 influences the response to neuropsychological tests, mini-mental state examination, digit span (DS), immediate and delayed prose memory, memory with interference at 10 and 30 seconds (MI 10 and 30), trail making tests (TMTs) A and B, abstraction task, verbal fluency (VF) test, figure drawing and copying, overlapping figures test and clock test were performed in 220 elderly men and women free from clinical dementia and from neurological and psychiatric diseases randomly taken from the Italian general population and analysed across the C825T polymorphism. The performance of DS, immediate and delayed prose memory, VF, and TMTs was worse in subjects who were TT for the polymorphism in comparison to the C-carriers. The performance of all tests declined with age. In the case of DS, immediate and delayed prose memory, MI 10 and VF, this trend was maintained in the C-carriers but not in TT. In the case of prose memory, of memory with interference, and of VF, schooling reduced the detrimental interaction between age and genotype. The C825T polymorphism of GNB3 gene therefore influences memory and verbal fluency, being additive to the effects of age and partially mitigated by schooling. Hindawi Publishing Corporation 2013 2013-10-22 /pmc/articles/PMC3819753/ /pubmed/24251036 http://dx.doi.org/10.1155/2013/597034 Text en Copyright © 2013 Edoardo Casiglia et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Casiglia, Edoardo Giordano, Nunzia Tikhonoff, Valérie Boschetti, Giovanni Mazza, Alberto Caffi, Sandro Guidotti, Federica Bisiacchi, Patrizia
spellingShingle	Casiglia, Edoardo Giordano, Nunzia Tikhonoff, Valérie Boschetti, Giovanni Mazza, Alberto Caffi, Sandro Guidotti, Federica Bisiacchi, Patrizia Cognitive Functions across the GNB3 C825T Polymorphism in an Elderly Italian Population
author_facet	Casiglia, Edoardo Giordano, Nunzia Tikhonoff, Valérie Boschetti, Giovanni Mazza, Alberto Caffi, Sandro Guidotti, Federica Bisiacchi, Patrizia
author_sort	Casiglia, Edoardo
title	Cognitive Functions across the GNB3 C825T Polymorphism in an Elderly Italian Population
title_short	Cognitive Functions across the GNB3 C825T Polymorphism in an Elderly Italian Population
title_full	Cognitive Functions across the GNB3 C825T Polymorphism in an Elderly Italian Population
title_fullStr	Cognitive Functions across the GNB3 C825T Polymorphism in an Elderly Italian Population
title_full_unstemmed	Cognitive Functions across the GNB3 C825T Polymorphism in an Elderly Italian Population
title_sort	cognitive functions across the gnb3 c825t polymorphism in an elderly italian population
description	To verify whether the C825T polymorphism of the GNB3 influences the response to neuropsychological tests, mini-mental state examination, digit span (DS), immediate and delayed prose memory, memory with interference at 10 and 30 seconds (MI 10 and 30), trail making tests (TMTs) A and B, abstraction task, verbal fluency (VF) test, figure drawing and copying, overlapping figures test and clock test were performed in 220 elderly men and women free from clinical dementia and from neurological and psychiatric diseases randomly taken from the Italian general population and analysed across the C825T polymorphism. The performance of DS, immediate and delayed prose memory, VF, and TMTs was worse in subjects who were TT for the polymorphism in comparison to the C-carriers. The performance of all tests declined with age. In the case of DS, immediate and delayed prose memory, MI 10 and VF, this trend was maintained in the C-carriers but not in TT. In the case of prose memory, of memory with interference, and of VF, schooling reduced the detrimental interaction between age and genotype. The C825T polymorphism of GNB3 gene therefore influences memory and verbal fluency, being additive to the effects of age and partially mitigated by schooling.
publisher	Hindawi Publishing Corporation
publishDate	2013
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3819753/
_version_	1612024060361834496

Cognitive Functions across the GNB3 C825T Polymorphism in an Elderly Italian Population

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