Bone marrow mesenchymal stem cells protect against retinal ganglion cell loss in aged rats with glaucoma

Glaucoma is a common eye disease in the aged population and has severe consequences. The present study examined the therapeutic effects of bone marrow mesenchymal stem cell (BMSC) transplantation in preventing loss of visual function in aged rats with glaucoma caused by laser-induced ocular hyperten...

Full description

Bibliographic Details
Main Authors:	Hu, Ying, Tan, Hai Bo, Wang, Xin Mei, Rong, Hua, Cui, Hong Ping, Cui, Hao
Format:	Online
Language:	English
Published:	Dove Medical Press 2013
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3817004/

id	pubmed-3817004
recordtype	oai_dc
spelling	pubmed-38170042013-11-07 Bone marrow mesenchymal stem cells protect against retinal ganglion cell loss in aged rats with glaucoma Hu, Ying Tan, Hai Bo Wang, Xin Mei Rong, Hua Cui, Hong Ping Cui, Hao Short Report Glaucoma is a common eye disease in the aged population and has severe consequences. The present study examined the therapeutic effects of bone marrow mesenchymal stem cell (BMSC) transplantation in preventing loss of visual function in aged rats with glaucoma caused by laser-induced ocular hypertension. We found that BMSCs promoted survival of retinal ganglion cells in the transplanted eye as compared with the control eye. Further, in swimming tests guided by visual cues, the rats with a BMSC transplant performed significantly better. We believe that BMSC transplantation therapy is effective in treating aged rats with glaucoma. Dove Medical Press 2013 2013-10-31 /pmc/articles/PMC3817004/ /pubmed/24204132 http://dx.doi.org/10.2147/CIA.S47350 Text en © 2013 Hu et al, publisher and licensee Dove Medical Press Ltd This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Hu, Ying Tan, Hai Bo Wang, Xin Mei Rong, Hua Cui, Hong Ping Cui, Hao
spellingShingle	Hu, Ying Tan, Hai Bo Wang, Xin Mei Rong, Hua Cui, Hong Ping Cui, Hao Bone marrow mesenchymal stem cells protect against retinal ganglion cell loss in aged rats with glaucoma
author_facet	Hu, Ying Tan, Hai Bo Wang, Xin Mei Rong, Hua Cui, Hong Ping Cui, Hao
author_sort	Hu, Ying
title	Bone marrow mesenchymal stem cells protect against retinal ganglion cell loss in aged rats with glaucoma
title_short	Bone marrow mesenchymal stem cells protect against retinal ganglion cell loss in aged rats with glaucoma
title_full	Bone marrow mesenchymal stem cells protect against retinal ganglion cell loss in aged rats with glaucoma
title_fullStr	Bone marrow mesenchymal stem cells protect against retinal ganglion cell loss in aged rats with glaucoma
title_full_unstemmed	Bone marrow mesenchymal stem cells protect against retinal ganglion cell loss in aged rats with glaucoma
title_sort	bone marrow mesenchymal stem cells protect against retinal ganglion cell loss in aged rats with glaucoma
description	Glaucoma is a common eye disease in the aged population and has severe consequences. The present study examined the therapeutic effects of bone marrow mesenchymal stem cell (BMSC) transplantation in preventing loss of visual function in aged rats with glaucoma caused by laser-induced ocular hypertension. We found that BMSCs promoted survival of retinal ganglion cells in the transplanted eye as compared with the control eye. Further, in swimming tests guided by visual cues, the rats with a BMSC transplant performed significantly better. We believe that BMSC transplantation therapy is effective in treating aged rats with glaucoma.
publisher	Dove Medical Press
publishDate	2013
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3817004/
_version_	1612023184444358656

Bone marrow mesenchymal stem cells protect against retinal ganglion cell loss in aged rats with glaucoma

Similar Items