Ratcheted diffusion transport through crowded nanochannels
The problem of transport through nanochannels is one of the major questions in cell biology, with a wide range of applications. In this paper we discuss the process of spontaneous translocation of molecules (Brownian particles) by ratcheted diffusion: a problem relevant for protein translocation alo...
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| Format: | Online |
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Nature Publishing Group
2013
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3813928/ |
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pubmed-3813928 |
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pubmed-38139282013-10-31 Ratcheted diffusion transport through crowded nanochannels Lappala, Anna Zaccone, Alessio Terentjev, Eugene M. Article The problem of transport through nanochannels is one of the major questions in cell biology, with a wide range of applications. In this paper we discuss the process of spontaneous translocation of molecules (Brownian particles) by ratcheted diffusion: a problem relevant for protein translocation along bacterial flagella or injectosome complex, or DNA translocation by bacteriophages. We use molecular dynamics simulations and statistical theory to identify two regimes of transport: at low rate of particle injection into the channel the process is controlled by the individual diffusion towards the open end (the first passage problem), while at a higher rate of injection the crowded regime sets in. In this regime the particle density in the channel reaches a constant saturation level and the resistance force increases substantially, due to the osmotic pressure build-up. To achieve a steady-state transport, the apparatus that injects new particles into a crowded channel has to operate with an increasing power consumption, proportional to the length of the channel and the required rate of transport. The analysis of resistance force, and accordingly – the power required to inject the particles into a crowded channel to overcome its clogging, is also relevant for many microfluidics applications. Nature Publishing Group 2013-10-31 /pmc/articles/PMC3813928/ /pubmed/24173137 http://dx.doi.org/10.1038/srep03103 Text en Copyright © 2013, Macmillan Publishers Limited. All rights reserved http://creativecommons.org/licenses/by-nc-nd/3.0/ This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/ |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Lappala, Anna Zaccone, Alessio Terentjev, Eugene M. |
| spellingShingle |
Lappala, Anna Zaccone, Alessio Terentjev, Eugene M. Ratcheted diffusion transport through crowded nanochannels |
| author_facet |
Lappala, Anna Zaccone, Alessio Terentjev, Eugene M. |
| author_sort |
Lappala, Anna |
| title |
Ratcheted diffusion transport through crowded nanochannels |
| title_short |
Ratcheted diffusion transport through crowded nanochannels |
| title_full |
Ratcheted diffusion transport through crowded nanochannels |
| title_fullStr |
Ratcheted diffusion transport through crowded nanochannels |
| title_full_unstemmed |
Ratcheted diffusion transport through crowded nanochannels |
| title_sort |
ratcheted diffusion transport through crowded nanochannels |
| description |
The problem of transport through nanochannels is one of the major questions in cell biology, with a wide range of applications. In this paper we discuss the process of spontaneous translocation of molecules (Brownian particles) by ratcheted diffusion: a problem relevant for protein translocation along bacterial flagella or injectosome complex, or DNA translocation by bacteriophages. We use molecular dynamics simulations and statistical theory to identify two regimes of transport: at low rate of particle injection into the channel the process is controlled by the individual diffusion towards the open end (the first passage problem), while at a higher rate of injection the crowded regime sets in. In this regime the particle density in the channel reaches a constant saturation level and the resistance force increases substantially, due to the osmotic pressure build-up. To achieve a steady-state transport, the apparatus that injects new particles into a crowded channel has to operate with an increasing power consumption, proportional to the length of the channel and the required rate of transport. The analysis of resistance force, and accordingly – the power required to inject the particles into a crowded channel to overcome its clogging, is also relevant for many microfluidics applications. |
| publisher |
Nature Publishing Group |
| publishDate |
2013 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3813928/ |
| _version_ |
1612022227218202624 |