Effect of the new synthetic vitamin E derivative ETS-GS on radiation enterocolitis symptoms in a rat model

Radiation enterocolitis is a severe adverse event that occurs after radiotherapy for malignant abdominal tumors. In this study, the therapeutic effects of ETS-GS, a novel vitamin E derivative with antioxidative and anti-inflammatory abilities, were examined in a rat model of radiation enterocolitis....

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Main Authors:	SUGITA, SATOSHI, INOMATA, MASAFUMI, KONO, YOHEI, SHIROSHITA, HIDEFUMI, ETOH, TSUYOSHI, SHIRAISHI, NORIO, KITANO, SEIGO
Format:	Online
Language:	English
Published:	D.A. Spandidos 2013
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3813668/

id	pubmed-3813668
recordtype	oai_dc
spelling	pubmed-38136682013-10-31 Effect of the new synthetic vitamin E derivative ETS-GS on radiation enterocolitis symptoms in a rat model SUGITA, SATOSHI INOMATA, MASAFUMI KONO, YOHEI SHIROSHITA, HIDEFUMI ETOH, TSUYOSHI SHIRAISHI, NORIO KITANO, SEIGO Articles Radiation enterocolitis is a severe adverse event that occurs after radiotherapy for malignant abdominal tumors. In this study, the therapeutic effects of ETS-GS, a novel vitamin E derivative with antioxidative and anti-inflammatory abilities, were examined in a rat model of radiation enterocolitis. The radiation enterocolitis model was created by irradiation of male rats with a single dose of 10 Gy. ETS-GS was administered subcutaneously (10 mg/kg/day) for five consecutive days from two days prior to irradiation. The animals were sacrificed three days after irradiation; following which, ileal tissue samples were analyzed for macroscopic and histological findings, presence of apoptosis, degree of oxidative stress and inflammation. In the irradiated group, severe erosion was observed in the small intestine in addition to necrosis of the mucosal layer, swelling and invasion of inflammatory cells of the submucosal layer, and shortening of the crypts. In irradiated rats that received ETS-GS, mucosal injury in the small intestine was milder compared with that of irradiated rats that received no ETS-GS. In addition, ETS-GS decreased apoptosis in the small intestine and reduced the activity of myeloperoxidase and malondialdehyde, which are markers for inflammation and oxidative stress. ETS-GS with antioxidant activity has a therapeutic effect on the symptoms of radiation enterocolitis in a rat model. D.A. Spandidos 2013-11 2013-09-12 /pmc/articles/PMC3813668/ /pubmed/24179500 http://dx.doi.org/10.3892/ol.2013.1581 Text en Copyright © 2013, Spandidos Publications http://creativecommons.org/licenses/by/3.0 This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	SUGITA, SATOSHI INOMATA, MASAFUMI KONO, YOHEI SHIROSHITA, HIDEFUMI ETOH, TSUYOSHI SHIRAISHI, NORIO KITANO, SEIGO
spellingShingle	SUGITA, SATOSHI INOMATA, MASAFUMI KONO, YOHEI SHIROSHITA, HIDEFUMI ETOH, TSUYOSHI SHIRAISHI, NORIO KITANO, SEIGO Effect of the new synthetic vitamin E derivative ETS-GS on radiation enterocolitis symptoms in a rat model
author_facet	SUGITA, SATOSHI INOMATA, MASAFUMI KONO, YOHEI SHIROSHITA, HIDEFUMI ETOH, TSUYOSHI SHIRAISHI, NORIO KITANO, SEIGO
author_sort	SUGITA, SATOSHI
title	Effect of the new synthetic vitamin E derivative ETS-GS on radiation enterocolitis symptoms in a rat model
title_short	Effect of the new synthetic vitamin E derivative ETS-GS on radiation enterocolitis symptoms in a rat model
title_full	Effect of the new synthetic vitamin E derivative ETS-GS on radiation enterocolitis symptoms in a rat model
title_fullStr	Effect of the new synthetic vitamin E derivative ETS-GS on radiation enterocolitis symptoms in a rat model
title_full_unstemmed	Effect of the new synthetic vitamin E derivative ETS-GS on radiation enterocolitis symptoms in a rat model
title_sort	effect of the new synthetic vitamin e derivative ets-gs on radiation enterocolitis symptoms in a rat model
description	Radiation enterocolitis is a severe adverse event that occurs after radiotherapy for malignant abdominal tumors. In this study, the therapeutic effects of ETS-GS, a novel vitamin E derivative with antioxidative and anti-inflammatory abilities, were examined in a rat model of radiation enterocolitis. The radiation enterocolitis model was created by irradiation of male rats with a single dose of 10 Gy. ETS-GS was administered subcutaneously (10 mg/kg/day) for five consecutive days from two days prior to irradiation. The animals were sacrificed three days after irradiation; following which, ileal tissue samples were analyzed for macroscopic and histological findings, presence of apoptosis, degree of oxidative stress and inflammation. In the irradiated group, severe erosion was observed in the small intestine in addition to necrosis of the mucosal layer, swelling and invasion of inflammatory cells of the submucosal layer, and shortening of the crypts. In irradiated rats that received ETS-GS, mucosal injury in the small intestine was milder compared with that of irradiated rats that received no ETS-GS. In addition, ETS-GS decreased apoptosis in the small intestine and reduced the activity of myeloperoxidase and malondialdehyde, which are markers for inflammation and oxidative stress. ETS-GS with antioxidant activity has a therapeutic effect on the symptoms of radiation enterocolitis in a rat model.
publisher	D.A. Spandidos
publishDate	2013
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3813668/
_version_	1612022118459899904

Effect of the new synthetic vitamin E derivative ETS-GS on radiation enterocolitis symptoms in a rat model

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