Prenatal Exposures and Anti-Müllerian Hormone in Female Adolescents: The Avon Longitudinal Study of Parents and Children

Given that the primordial ovarian follicular pool is established in utero, it may be influenced by parental characteristics and the intrauterine environment. Anti-Müllerian hormone (AMH) levels are increasingly recognized as a biomarker of ovarian reserve in females in adulthood and adolescence. We...

Full description

Bibliographic Details
Main Authors:	Fraser, Abigail, McNally, William, Sattar, Naveed, Anderson, Emma L., Lashen, Hany, Fleming, Richard, Lawlor, Debbie A., Nelson, Scott M.
Format:	Online
Language:	English
Published:	Oxford University Press 2013
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3813311/

id	pubmed-3813311
recordtype	oai_dc
spelling	pubmed-38133112013-10-31 Prenatal Exposures and Anti-Müllerian Hormone in Female Adolescents: The Avon Longitudinal Study of Parents and Children Fraser, Abigail McNally, William Sattar, Naveed Anderson, Emma L. Lashen, Hany Fleming, Richard Lawlor, Debbie A. Nelson, Scott M. Original Contributions Given that the primordial ovarian follicular pool is established in utero, it may be influenced by parental characteristics and the intrauterine environment. Anti-Müllerian hormone (AMH) levels are increasingly recognized as a biomarker of ovarian reserve in females in adulthood and adolescence. We examined and compared associations of maternal and paternal prenatal exposures with AMH levels in adolescent (mean age, 15.4 years) female offspring (n = 1,399) using data from the Avon Longitudinal Study of Parents and Children, a United Kingdom birth cohort study that originated in 1991 and is still ongoing (data are from 1991–2008). The median AMH level was 3.67 ng/mL (interquartile range: 2.46–5.57). Paternal but not maternal smoking prior to and during pregnancy were inversely associated with AMH levels. No or irregular maternal menstrual cycles before pregnancy were associated with higher AMH levels in daughter during adolescence. High maternal gestational weight gain (top fifth versus the rest of the distribution) was associated with lower AMH levels in daughters. Parental age, body mass index, and alcohol intake during pregnancy, child's birth weight, and maternal parity and time to conception were not associated with daughters' AMH levels. Our results suggest that some parental preconceptual characteristics and environmental exposures while the child is in utero may influence the long-term ovarian development and function in female offspring. Oxford University Press 2013-11-01 2013-09-05 /pmc/articles/PMC3813311/ /pubmed/24008900 http://dx.doi.org/10.1093/aje/kwt137 Text en © The Author 2013. Published by Oxford University Press on behalf of the Johns Hopkins Bloomberg School of Public Health. http://creativecommons.org/licenses/by-nc/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Fraser, Abigail McNally, William Sattar, Naveed Anderson, Emma L. Lashen, Hany Fleming, Richard Lawlor, Debbie A. Nelson, Scott M.
spellingShingle	Fraser, Abigail McNally, William Sattar, Naveed Anderson, Emma L. Lashen, Hany Fleming, Richard Lawlor, Debbie A. Nelson, Scott M. Prenatal Exposures and Anti-Müllerian Hormone in Female Adolescents: The Avon Longitudinal Study of Parents and Children
author_facet	Fraser, Abigail McNally, William Sattar, Naveed Anderson, Emma L. Lashen, Hany Fleming, Richard Lawlor, Debbie A. Nelson, Scott M.
author_sort	Fraser, Abigail
title	Prenatal Exposures and Anti-Müllerian Hormone in Female Adolescents: The Avon Longitudinal Study of Parents and Children
title_short	Prenatal Exposures and Anti-Müllerian Hormone in Female Adolescents: The Avon Longitudinal Study of Parents and Children
title_full	Prenatal Exposures and Anti-Müllerian Hormone in Female Adolescents: The Avon Longitudinal Study of Parents and Children
title_fullStr	Prenatal Exposures and Anti-Müllerian Hormone in Female Adolescents: The Avon Longitudinal Study of Parents and Children
title_full_unstemmed	Prenatal Exposures and Anti-Müllerian Hormone in Female Adolescents: The Avon Longitudinal Study of Parents and Children
title_sort	prenatal exposures and anti-müllerian hormone in female adolescents: the avon longitudinal study of parents and children
description	Given that the primordial ovarian follicular pool is established in utero, it may be influenced by parental characteristics and the intrauterine environment. Anti-Müllerian hormone (AMH) levels are increasingly recognized as a biomarker of ovarian reserve in females in adulthood and adolescence. We examined and compared associations of maternal and paternal prenatal exposures with AMH levels in adolescent (mean age, 15.4 years) female offspring (n = 1,399) using data from the Avon Longitudinal Study of Parents and Children, a United Kingdom birth cohort study that originated in 1991 and is still ongoing (data are from 1991–2008). The median AMH level was 3.67 ng/mL (interquartile range: 2.46–5.57). Paternal but not maternal smoking prior to and during pregnancy were inversely associated with AMH levels. No or irregular maternal menstrual cycles before pregnancy were associated with higher AMH levels in daughter during adolescence. High maternal gestational weight gain (top fifth versus the rest of the distribution) was associated with lower AMH levels in daughters. Parental age, body mass index, and alcohol intake during pregnancy, child's birth weight, and maternal parity and time to conception were not associated with daughters' AMH levels. Our results suggest that some parental preconceptual characteristics and environmental exposures while the child is in utero may influence the long-term ovarian development and function in female offspring.
publisher	Oxford University Press
publishDate	2013
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3813311/
_version_	1612022006000123904

Prenatal Exposures and Anti-Müllerian Hormone in Female Adolescents: The Avon Longitudinal Study of Parents and Children

Similar Items