A Preliminary Investigation of the Jack-Bean Urease Inhibition by Randomly Selected Traditionally Used Herbal Medicine

A Preliminary Investigation of the Jack-Bean Urease Inhibition by Randomly Selected Traditionally Used Herbal Medicine

Helicobacter pylori (H. pylori) infection leads to different clinical and pathological outcomes in humans, including chronic gastritis, peptic ulcer disease and gastric neoplasia and even gastric cancer and its eradiation dependst upon multi-drug therapy. The most effective therapy is still unknown...

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Main Authors: Biglar, Mahmood, Soltani, Khadijeh, Nabati, Farzaneh, Bazl, Roya, Mojab, Faraz, Amanlou, Massoud
Format: Online
Language:English
Published: Shaheed Beheshti University of Medical Sciences 2012
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3813127/
id pubmed-3813127
recordtype oai_dc
spelling pubmed-38131272013-11-18 A Preliminary Investigation of the Jack-Bean Urease Inhibition by Randomly Selected Traditionally Used Herbal Medicine Biglar, Mahmood Soltani, Khadijeh Nabati, Farzaneh Bazl, Roya Mojab, Faraz Amanlou, Massoud Original Article Helicobacter pylori (H. pylori) infection leads to different clinical and pathological outcomes in humans, including chronic gastritis, peptic ulcer disease and gastric neoplasia and even gastric cancer and its eradiation dependst upon multi-drug therapy. The most effective therapy is still unknown and prompts people to make great efforts to find better and more modern natural or synthetic anti-H. pylori agents. In this report 21 randomly selected herbal methanolic extracts were evaluated for their effect on inhibition of Jack-bean urease using the indophenol method as described by Weatherburn. The inhibition potency was measured by UV spectroscopy technique at 630 nm which attributes to released ammonium. Among these extracts, five showed potent inhibitory activities with IC50 ranges of 18-35 μg/mL. These plants are Matricaria disciforme (IC50:35 μg/mL), Nasturtium officinale (IC50:18 μg/mL), Punica granatum (IC50:30 μg/mL), Camelia sinensis (IC50:35 μg/mL), Citrus aurantifolia (IC50:28 μg/mL). Shaheed Beheshti University of Medical Sciences 2012 /pmc/articles/PMC3813127/ /pubmed/24250509 Text en © 2012 by School of Pharmacy, Shaheed Beheshti University of Medical Sciences and Health Services This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
repository_type Open Access Journal
institution_category Foreign Institution
institution US National Center for Biotechnology Information
building NCBI PubMed
collection Online Access
language English
format Online
author Biglar, Mahmood
Soltani, Khadijeh
Nabati, Farzaneh
Bazl, Roya
Mojab, Faraz
Amanlou, Massoud
spellingShingle Biglar, Mahmood
Soltani, Khadijeh
Nabati, Farzaneh
Bazl, Roya
Mojab, Faraz
Amanlou, Massoud
A Preliminary Investigation of the Jack-Bean Urease Inhibition by Randomly Selected Traditionally Used Herbal Medicine
author_facet Biglar, Mahmood
Soltani, Khadijeh
Nabati, Farzaneh
Bazl, Roya
Mojab, Faraz
Amanlou, Massoud
author_sort Biglar, Mahmood
title A Preliminary Investigation of the Jack-Bean Urease Inhibition by Randomly Selected Traditionally Used Herbal Medicine
title_short A Preliminary Investigation of the Jack-Bean Urease Inhibition by Randomly Selected Traditionally Used Herbal Medicine
title_full A Preliminary Investigation of the Jack-Bean Urease Inhibition by Randomly Selected Traditionally Used Herbal Medicine
title_fullStr A Preliminary Investigation of the Jack-Bean Urease Inhibition by Randomly Selected Traditionally Used Herbal Medicine
title_full_unstemmed A Preliminary Investigation of the Jack-Bean Urease Inhibition by Randomly Selected Traditionally Used Herbal Medicine
title_sort preliminary investigation of the jack-bean urease inhibition by randomly selected traditionally used herbal medicine
description Helicobacter pylori (H. pylori) infection leads to different clinical and pathological outcomes in humans, including chronic gastritis, peptic ulcer disease and gastric neoplasia and even gastric cancer and its eradiation dependst upon multi-drug therapy. The most effective therapy is still unknown and prompts people to make great efforts to find better and more modern natural or synthetic anti-H. pylori agents. In this report 21 randomly selected herbal methanolic extracts were evaluated for their effect on inhibition of Jack-bean urease using the indophenol method as described by Weatherburn. The inhibition potency was measured by UV spectroscopy technique at 630 nm which attributes to released ammonium. Among these extracts, five showed potent inhibitory activities with IC50 ranges of 18-35 μg/mL. These plants are Matricaria disciforme (IC50:35 μg/mL), Nasturtium officinale (IC50:18 μg/mL), Punica granatum (IC50:30 μg/mL), Camelia sinensis (IC50:35 μg/mL), Citrus aurantifolia (IC50:28 μg/mL).
publisher Shaheed Beheshti University of Medical Sciences
publishDate 2012
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3813127/
_version_ 1612021913921519616

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