Asymmetric and Symmetric Dimethylarginine in Adolescents with Hyperuricemia

The purpose of this work was to investigate if in adolescents with hyperuricemia serum levels of asymmetric and symmetric dimethylarginine (ADMA, SDMA) are increased and if their levels correlate with serum uric acid (UA). Patients and Methods. The study group consisted of 58 hyperuricemic patients...

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Main Authors:	Tenderenda-Banasiuk, Edyta, Wasilewska, Anna, Taranta-Janusz, Katarzyna, Korzeniecka-Kozerska, Agata
Format:	Online
Language:	English
Published:	Hindawi Publishing Corporation 2013
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3810106/

id	pubmed-3810106
recordtype	oai_dc
spelling	pubmed-38101062013-11-10 Asymmetric and Symmetric Dimethylarginine in Adolescents with Hyperuricemia Tenderenda-Banasiuk, Edyta Wasilewska, Anna Taranta-Janusz, Katarzyna Korzeniecka-Kozerska, Agata Clinical Study The purpose of this work was to investigate if in adolescents with hyperuricemia serum levels of asymmetric and symmetric dimethylarginine (ADMA, SDMA) are increased and if their levels correlate with serum uric acid (UA). Patients and Methods. The study group consisted of 58 hyperuricemic patients aged median 16.15 Q1–Q3 (14–17). The reference group contained 27 healthy individuals with normal serum UA level. ADMA and SDMA were measured by immunoenzymatic ELISA commercial kits and expressed in μmol/L. Serum UA was measured by the colorimetric method. Results. In hyperuricemic patients serum ADMA values did not differ between two estimated groups (P > 0.05); however, SDMA was significantly higher than in reference group (P < 0.01). Serum ADMA and SDMA correlated positively with UA (r = 0.34, P < 0.01) (r = 0.31, P < 0.01) and hs-CRP (r = 0.20, P < 0.05) (r = 0.36, P < 0.01), respectively. Conclusion. We demonstrated increased SDMA but not ADMA levels in adolescents with hyperuricemia and their correlation with serum uric acid levels. However, at the moment it is difficult to answer the question if it is just coexistence of these factors or any mechanism linking uric acid and methylated arginines really exists. Hindawi Publishing Corporation 2013 2013-09-26 /pmc/articles/PMC3810106/ /pubmed/24223456 http://dx.doi.org/10.1155/2013/267697 Text en Copyright © 2013 Edyta Tenderenda-Banasiuk et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Tenderenda-Banasiuk, Edyta Wasilewska, Anna Taranta-Janusz, Katarzyna Korzeniecka-Kozerska, Agata
spellingShingle	Tenderenda-Banasiuk, Edyta Wasilewska, Anna Taranta-Janusz, Katarzyna Korzeniecka-Kozerska, Agata Asymmetric and Symmetric Dimethylarginine in Adolescents with Hyperuricemia
author_facet	Tenderenda-Banasiuk, Edyta Wasilewska, Anna Taranta-Janusz, Katarzyna Korzeniecka-Kozerska, Agata
author_sort	Tenderenda-Banasiuk, Edyta
title	Asymmetric and Symmetric Dimethylarginine in Adolescents with Hyperuricemia
title_short	Asymmetric and Symmetric Dimethylarginine in Adolescents with Hyperuricemia
title_full	Asymmetric and Symmetric Dimethylarginine in Adolescents with Hyperuricemia
title_fullStr	Asymmetric and Symmetric Dimethylarginine in Adolescents with Hyperuricemia
title_full_unstemmed	Asymmetric and Symmetric Dimethylarginine in Adolescents with Hyperuricemia
title_sort	asymmetric and symmetric dimethylarginine in adolescents with hyperuricemia
description	The purpose of this work was to investigate if in adolescents with hyperuricemia serum levels of asymmetric and symmetric dimethylarginine (ADMA, SDMA) are increased and if their levels correlate with serum uric acid (UA). Patients and Methods. The study group consisted of 58 hyperuricemic patients aged median 16.15 Q1–Q3 (14–17). The reference group contained 27 healthy individuals with normal serum UA level. ADMA and SDMA were measured by immunoenzymatic ELISA commercial kits and expressed in μmol/L. Serum UA was measured by the colorimetric method. Results. In hyperuricemic patients serum ADMA values did not differ between two estimated groups (P > 0.05); however, SDMA was significantly higher than in reference group (P < 0.01). Serum ADMA and SDMA correlated positively with UA (r = 0.34, P < 0.01) (r = 0.31, P < 0.01) and hs-CRP (r = 0.20, P < 0.05) (r = 0.36, P < 0.01), respectively. Conclusion. We demonstrated increased SDMA but not ADMA levels in adolescents with hyperuricemia and their correlation with serum uric acid levels. However, at the moment it is difficult to answer the question if it is just coexistence of these factors or any mechanism linking uric acid and methylated arginines really exists.
publisher	Hindawi Publishing Corporation
publishDate	2013
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3810106/
_version_	1612021162544463872

Asymmetric and Symmetric Dimethylarginine in Adolescents with Hyperuricemia

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