High-efficiency liposomal encapsulation of a tyrosine kinase inhibitor leads to improved in vivo toxicity and tumor response profile

High-efficiency liposomal encapsulation of a tyrosine kinase inhibitor leads to improved in vivo toxicity and tumor response profile

Staurosporine (STS) is a potent pan-kinase inhibitor with marked activity against several chemotherapy-resistant tumor types in vitro. The translational progress of this compound has been hindered by poor pharmacokinetics and toxicity. We sought to determine whether liposomal encapsulation of STS wo...

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Bibliographic Details
Main Authors: Mukthavaram, Rajesh, Jiang, Pengfei, Saklecha, Rohit, Simberg, Dmitri, Bharati, Ila Sri, Nomura, Natsuko, Chao, Ying, Pastorino, Sandra, Pingle, Sandeep C, Fogal, Valentina, Wrasidlo, Wolf, Makale, Milan, Kesari, Santosh
Format: Online
Language:English
Published: Dove Medical Press 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3808212/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3808212/

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