JAK1 truncating mutations in gynecologic cancer define new role of cancer-associated protein tyrosine kinase aberrations

JAK1 truncating mutations in gynecologic cancer define new role of cancer-associated protein tyrosine kinase aberrations

Cancer-associated protein tyrosine kinase (PTK) mutations usually are gain-of-function (GOF) mutations that drive tumor growth and metastasis. We have found 50 JAK1 truncating mutations in 36 of 635 gynecologic tumors in the Total Cancer Care® (TCC®) tumor bank. Among cancer cell lines containing JA...

Full description

Bibliographic Details
Main Authors: Ren, Yuan, Zhang, Yonghong, Liu, Richard Z., Fenstermacher, David A., Wright, Kenneth L., Teer, Jamie K., Wu, Jie
Format: Online
Language:English
Published: Nature Publishing Group 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3807107/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3807107/

Similar Items