Pathophysiological power of improper tonic GABAA conductances in mature and immature models

High-affinity extrasynaptic gamma-aminobutyric acid A (GABAA) receptors are tonically activated by low and consistent levels of ambient GABA, mediating chronic inhibition against neuronal excitability (tonic inhibition) and the modulation of neural development. Synaptic (phasic) inhibition is spatia...

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Bibliographic Details
Main Authors: Egawa, Kiyoshi, Fukuda, Atsuo
Format: Online
Language:English
Published: Frontiers Media S.A. 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3807051/