Cell-mediated reduction of human β-defensin 1: a major role for mucosal thioredoxin

Cell-mediated reduction of human β-defensin 1: a major role for mucosal thioredoxin

Human β-defensin 1 (hBD-1) is an antimicrobial peptide expressed by epithelia and hematopoietic cells. We demonstrated recently that hBD-1 shows activity against enteric commensals and Candida species only after its disulfide bonds have been reduced by thioredoxin (TRX) or a reducing environment. He...

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Bibliographic Details
Main Authors: Jaeger, S U, Schroeder, B O, Meyer-Hoffert, U, Courth, L, Fehr, S N, Gersemann, M, Stange, E F, Wehkamp, J
Format: Online
Language:English
Published: Nature Publishing Group 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3806438/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3806438/

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