Sphingomyelin Liposomes Containing Soluble Leishmania major antigens Induced Strong Th2 Immune Response in BALB/c Mice

Objective(s): Soluble Leishmania antigens (SLA) provide suitable protection against leishmaniasis in murine model when delivered by an appropriate delivery system. Liposomes have been shown to be suitable vaccine delivery systems against leishmaniasis, however, the phospholipase-A (PLA) activity of...

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Bibliographic Details
Main Authors: Chavoshian, Omid, Biari, Nazanin, Badiee, Ali, Khamesipour, Ali, Abbasi, Azam, Saberi, Zahra, Jalali, Seyed Amir, Jaafari, Mahmoud Reza
Format: Online
Language:English
Published: Mashhad University of Medical Sciences 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3804844/
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Summary:Objective(s): Soluble Leishmania antigens (SLA) provide suitable protection against leishmaniasis in murine model when delivered by an appropriate delivery system. Liposomes have been shown to be suitable vaccine delivery systems against leishmaniasis, however, the phospholipase-A (PLA) activity of SLA is a drawback to prepare a stable liposomal SLA. One strategy to overcome this problem might be using a lipid which is resistant to PLA activity of SLA such as sphingomyelin (SM). The aim of this study was to evaluate the effect of stable SM liposomes containing SLA on the immune response induced against leishmaniasis in BALB/c mice .