GKAP/SAPAP orchestrates activity-dependent postsynaptic protein remodeling and homeostatic scaling

GKAP/SAPAP orchestrates activity-dependent postsynaptic protein remodeling and homeostatic scaling

How does chronic activity modulation lead to global remodeling of proteins at synapses and synaptic scaling? Here we report a role of guanylate-kinase-associated-protein (GKAP; also known as SAPAP), a scaffolding molecule linking NMDA receptor-PSD-95 to Shank-Homer complexes, in these processes. Ove...

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Bibliographic Details
Main Authors: Shin, Seung Min, Zhang, Nanyan, Hansen, Jonathan, Gerges, Nashaat Z., Pak, Daniel T.S., Sheng, Morgan, Lee, Sang H.
Format: Online
Language:English
Published: 2012
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3804128/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3804128/

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