Whole genome comparison of donor and cloned dogs
Cloning is a process that produces genetically identical organisms. However, the genomic degree of genetic resemblance in clones needs to be determined. In this report, the genomes of a cloned dog and its donor were compared. Compared with a human monozygotic twin, the genome of the cloned dog showe...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Online |
| Language: | English |
| Published: |
Nature Publishing Group
2013
|
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3801109/ |
| id |
pubmed-3801109 |
|---|---|
| recordtype |
oai_dc |
| spelling |
pubmed-38011092013-10-21 Whole genome comparison of donor and cloned dogs Kim, Hak-Min Cho, Yun Sung Kim, Hyunmin Jho, Sungwoong Son, Bongjun Choi, Joung Yoon Kim, Sangsoo Lee, Byeong Chun Bhak, Jong Jang, Goo Article Cloning is a process that produces genetically identical organisms. However, the genomic degree of genetic resemblance in clones needs to be determined. In this report, the genomes of a cloned dog and its donor were compared. Compared with a human monozygotic twin, the genome of the cloned dog showed little difference from the genome of the nuclear donor dog in terms of single nucleotide variations, chromosomal instability, and telomere lengths. These findings suggest that cloning by somatic cell nuclear transfer produced an almost identical genome. The whole genome sequence data of donor and cloned dogs can provide a resource for further investigations on epigenetic contributions in phenotypic differences. Nature Publishing Group 2013-10-21 /pmc/articles/PMC3801109/ /pubmed/24141358 http://dx.doi.org/10.1038/srep02998 Text en Copyright © 2013, Macmillan Publishers Limited. All rights reserved http://creativecommons.org/licenses/by/3.0/ This work is licensed under a Creative Commons Attribution 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by/3.0/ |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Kim, Hak-Min Cho, Yun Sung Kim, Hyunmin Jho, Sungwoong Son, Bongjun Choi, Joung Yoon Kim, Sangsoo Lee, Byeong Chun Bhak, Jong Jang, Goo |
| spellingShingle |
Kim, Hak-Min Cho, Yun Sung Kim, Hyunmin Jho, Sungwoong Son, Bongjun Choi, Joung Yoon Kim, Sangsoo Lee, Byeong Chun Bhak, Jong Jang, Goo Whole genome comparison of donor and cloned dogs |
| author_facet |
Kim, Hak-Min Cho, Yun Sung Kim, Hyunmin Jho, Sungwoong Son, Bongjun Choi, Joung Yoon Kim, Sangsoo Lee, Byeong Chun Bhak, Jong Jang, Goo |
| author_sort |
Kim, Hak-Min |
| title |
Whole genome comparison of donor and cloned dogs |
| title_short |
Whole genome comparison of donor and cloned dogs |
| title_full |
Whole genome comparison of donor and cloned dogs |
| title_fullStr |
Whole genome comparison of donor and cloned dogs |
| title_full_unstemmed |
Whole genome comparison of donor and cloned dogs |
| title_sort |
whole genome comparison of donor and cloned dogs |
| description |
Cloning is a process that produces genetically identical organisms. However, the genomic degree of genetic resemblance in clones needs to be determined. In this report, the genomes of a cloned dog and its donor were compared. Compared with a human monozygotic twin, the genome of the cloned dog showed little difference from the genome of the nuclear donor dog in terms of single nucleotide variations, chromosomal instability, and telomere lengths. These findings suggest that cloning by somatic cell nuclear transfer produced an almost identical genome. The whole genome sequence data of donor and cloned dogs can provide a resource for further investigations on epigenetic contributions in phenotypic differences. |
| publisher |
Nature Publishing Group |
| publishDate |
2013 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3801109/ |
| _version_ |
1612019571680608256 |