The Fragile X Protein binds mRNAs involved in cancer progression and modulates metastasis formation
The role of the fragile X mental retardation protein (FMRP) is well established in brain, where its absence leads to the fragile X syndrome (FXS). FMRP is almost ubiquitously expressed, suggesting that, in addition to its effects in brain, it may have fundamental roles in other organs. There is evid...
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| Format: | Online |
| Language: | English |
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Blackwell Publishing Ltd
2013
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3799577/ |
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pubmed-3799577 |
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pubmed-37995772013-10-23 The Fragile X Protein binds mRNAs involved in cancer progression and modulates metastasis formation Lucá, Rossella Averna, Michele Zalfa, Francesca Vecchi, Manuela Bianchi, Fabrizio Fata, Giorgio La Del Nonno, Franca Nardacci, Roberta Bianchi, Marco Nuciforo, Paolo Munck, Sebastian Parrella, Paola Moura, Rute Signori, Emanuela Alston, Robert Kuchnio, Anna Farace, Maria Giulia Fazio, Vito Michele Piacentini, Mauro De Strooper, Bart Achsel, Tilmann Neri, Giovanni Neven, Patrick Evans, D Gareth Carmeliet, Peter Mazzone, Massimiliano Bagni, Claudia Research Articles The role of the fragile X mental retardation protein (FMRP) is well established in brain, where its absence leads to the fragile X syndrome (FXS). FMRP is almost ubiquitously expressed, suggesting that, in addition to its effects in brain, it may have fundamental roles in other organs. There is evidence that FMRP expression can be linked to cancer. FMR1 mRNA, encoding FMRP, is overexpressed in hepatocellular carcinoma cells. A decreased risk of cancer has been reported in patients with FXS while a patient-case with FXS showed an unusual decrease of tumour brain invasiveness. However, a role for FMRP in regulating cancer biology, if any, remains unknown. We show here that FMRP and FMR1 mRNA levels correlate with prognostic indicators of aggressive breast cancer, lung metastases probability and triple negative breast cancer (TNBC). We establish that FMRP overexpression in murine breast primary tumours enhances lung metastasis while its reduction has the opposite effect regulating cell spreading and invasion. FMRP binds mRNAs involved in epithelial mesenchymal transition (EMT) and invasion including E-cadherin and Vimentin mRNAs, hallmarks of EMT and cancer progression. Blackwell Publishing Ltd 2013-10 2013-09-16 /pmc/articles/PMC3799577/ /pubmed/24092663 http://dx.doi.org/10.1002/emmm.201302847 Text en © 2013 The Authors. Published by John Wiley and Sons, Ltd on behalf of EMBO http://creativecommons.org/licenses/by/2.5/ Re-use of this article is permitted in accordance with the Creative Commons Deed, Attribution 2.5, which does not permit commercial exploitation. |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Lucá, Rossella Averna, Michele Zalfa, Francesca Vecchi, Manuela Bianchi, Fabrizio Fata, Giorgio La Del Nonno, Franca Nardacci, Roberta Bianchi, Marco Nuciforo, Paolo Munck, Sebastian Parrella, Paola Moura, Rute Signori, Emanuela Alston, Robert Kuchnio, Anna Farace, Maria Giulia Fazio, Vito Michele Piacentini, Mauro De Strooper, Bart Achsel, Tilmann Neri, Giovanni Neven, Patrick Evans, D Gareth Carmeliet, Peter Mazzone, Massimiliano Bagni, Claudia |
| spellingShingle |
Lucá, Rossella Averna, Michele Zalfa, Francesca Vecchi, Manuela Bianchi, Fabrizio Fata, Giorgio La Del Nonno, Franca Nardacci, Roberta Bianchi, Marco Nuciforo, Paolo Munck, Sebastian Parrella, Paola Moura, Rute Signori, Emanuela Alston, Robert Kuchnio, Anna Farace, Maria Giulia Fazio, Vito Michele Piacentini, Mauro De Strooper, Bart Achsel, Tilmann Neri, Giovanni Neven, Patrick Evans, D Gareth Carmeliet, Peter Mazzone, Massimiliano Bagni, Claudia The Fragile X Protein binds mRNAs involved in cancer progression and modulates metastasis formation |
| author_facet |
Lucá, Rossella Averna, Michele Zalfa, Francesca Vecchi, Manuela Bianchi, Fabrizio Fata, Giorgio La Del Nonno, Franca Nardacci, Roberta Bianchi, Marco Nuciforo, Paolo Munck, Sebastian Parrella, Paola Moura, Rute Signori, Emanuela Alston, Robert Kuchnio, Anna Farace, Maria Giulia Fazio, Vito Michele Piacentini, Mauro De Strooper, Bart Achsel, Tilmann Neri, Giovanni Neven, Patrick Evans, D Gareth Carmeliet, Peter Mazzone, Massimiliano Bagni, Claudia |
| author_sort |
Lucá, Rossella |
| title |
The Fragile X Protein binds mRNAs involved in cancer progression and modulates metastasis formation |
| title_short |
The Fragile X Protein binds mRNAs involved in cancer progression and modulates metastasis formation |
| title_full |
The Fragile X Protein binds mRNAs involved in cancer progression and modulates metastasis formation |
| title_fullStr |
The Fragile X Protein binds mRNAs involved in cancer progression and modulates metastasis formation |
| title_full_unstemmed |
The Fragile X Protein binds mRNAs involved in cancer progression and modulates metastasis formation |
| title_sort |
fragile x protein binds mrnas involved in cancer progression and modulates metastasis formation |
| description |
The role of the fragile X mental retardation protein (FMRP) is well established in brain, where its absence leads to the fragile X syndrome (FXS). FMRP is almost ubiquitously expressed, suggesting that, in addition to its effects in brain, it may have fundamental roles in other organs. There is evidence that FMRP expression can be linked to cancer. FMR1 mRNA, encoding FMRP, is overexpressed in hepatocellular carcinoma cells. A decreased risk of cancer has been reported in patients with FXS while a patient-case with FXS showed an unusual decrease of tumour brain invasiveness. However, a role for FMRP in regulating cancer biology, if any, remains unknown. We show here that FMRP and FMR1 mRNA levels correlate with prognostic indicators of aggressive breast cancer, lung metastases probability and triple negative breast cancer (TNBC). We establish that FMRP overexpression in murine breast primary tumours enhances lung metastasis while its reduction has the opposite effect regulating cell spreading and invasion. FMRP binds mRNAs involved in epithelial mesenchymal transition (EMT) and invasion including E-cadherin and Vimentin mRNAs, hallmarks of EMT and cancer progression. |
| publisher |
Blackwell Publishing Ltd |
| publishDate |
2013 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3799577/ |
| _version_ |
1612019147247452160 |