DNA Methylation in Peripheral Blood: A Potential Biomarker for Cancer Molecular Epidemiology
Aberrant DNA methylation is associated with cancer development and progression. There are several types of specimens from which DNA methylation pattern can be measured and evaluated as an indicator of disease status (from normal biological process to pathologic condition) and even of pharmacologic r...
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| Format: | Online |
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Japan Epidemiological Association
2012
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3798632/ |
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pubmed-3798632 |
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oai_dc |
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pubmed-37986322013-12-03 DNA Methylation in Peripheral Blood: A Potential Biomarker for Cancer Molecular Epidemiology Li, Lian Choi, Ji-Yeob Lee, Kyoung-Mu Sung, Hyuna Park, Sue K. Oze, Isao Pan, Kai-Feng You, Wei-Cheng Chen, Ying-Xuan Fang, Jing-Yuan Matsuo, Keitaro Kim, Woo Ho Yuasa, Yasuhito Kang, Daehee Review Article Aberrant DNA methylation is associated with cancer development and progression. There are several types of specimens from which DNA methylation pattern can be measured and evaluated as an indicator of disease status (from normal biological process to pathologic condition) and even of pharmacologic response to therapy. Blood-based specimens such as cell-free circulating nucleic acid and DNA extracted from leukocytes in peripheral blood may be a potential source of noninvasive cancer biomarkers. In this article, we describe the characteristics of blood-based DNA methylation from different biological sources, detection methods, and the factors affecting DNA methylation. We provide a comprehensive literature review of blood-based DNA methylation as a cancer biomarker and focus on the study of DNA methylation using peripheral blood leukocytes. Although DNA methylation patterns measured in peripheral blood have great potential to be useful and informative biomarkers of cancer risk and prognosis, large systematic and unbiased prospective studies that consider biological plausibility and data analysis issues will be needed in order to develop a clinically feasible blood-based assay. Japan Epidemiological Association 2012-09-05 /pmc/articles/PMC3798632/ /pubmed/22863985 http://dx.doi.org/10.2188/jea.JE20120003 Text en © 2012 Japan Epidemiological Association. http://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the terms of Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Li, Lian Choi, Ji-Yeob Lee, Kyoung-Mu Sung, Hyuna Park, Sue K. Oze, Isao Pan, Kai-Feng You, Wei-Cheng Chen, Ying-Xuan Fang, Jing-Yuan Matsuo, Keitaro Kim, Woo Ho Yuasa, Yasuhito Kang, Daehee |
| spellingShingle |
Li, Lian Choi, Ji-Yeob Lee, Kyoung-Mu Sung, Hyuna Park, Sue K. Oze, Isao Pan, Kai-Feng You, Wei-Cheng Chen, Ying-Xuan Fang, Jing-Yuan Matsuo, Keitaro Kim, Woo Ho Yuasa, Yasuhito Kang, Daehee DNA Methylation in Peripheral Blood: A Potential Biomarker for Cancer Molecular Epidemiology |
| author_facet |
Li, Lian Choi, Ji-Yeob Lee, Kyoung-Mu Sung, Hyuna Park, Sue K. Oze, Isao Pan, Kai-Feng You, Wei-Cheng Chen, Ying-Xuan Fang, Jing-Yuan Matsuo, Keitaro Kim, Woo Ho Yuasa, Yasuhito Kang, Daehee |
| author_sort |
Li, Lian |
| title |
DNA Methylation in Peripheral Blood: A Potential Biomarker for Cancer Molecular Epidemiology |
| title_short |
DNA Methylation in Peripheral Blood: A Potential Biomarker for Cancer Molecular Epidemiology |
| title_full |
DNA Methylation in Peripheral Blood: A Potential Biomarker for Cancer Molecular Epidemiology |
| title_fullStr |
DNA Methylation in Peripheral Blood: A Potential Biomarker for Cancer Molecular Epidemiology |
| title_full_unstemmed |
DNA Methylation in Peripheral Blood: A Potential Biomarker for Cancer Molecular Epidemiology |
| title_sort |
dna methylation in peripheral blood: a potential biomarker for cancer molecular epidemiology |
| description |
Aberrant DNA methylation is associated with cancer development and progression. There are several types of specimens from which DNA methylation pattern can be measured and evaluated as an indicator of disease status (from normal biological process to pathologic condition) and even of pharmacologic response to therapy. Blood-based specimens such as cell-free circulating nucleic acid and DNA extracted from leukocytes in peripheral blood may be a potential source of noninvasive cancer biomarkers. In this article, we describe the characteristics of blood-based DNA methylation from different biological sources, detection methods, and the factors affecting DNA methylation. We provide a comprehensive literature review of blood-based DNA methylation as a cancer biomarker and focus on the study of DNA methylation using peripheral blood leukocytes. Although DNA methylation patterns measured in peripheral blood have great potential to be useful and informative biomarkers of cancer risk and prognosis, large systematic and unbiased prospective studies that consider biological plausibility and data analysis issues will be needed in order to develop a clinically feasible blood-based assay. |
| publisher |
Japan Epidemiological Association |
| publishDate |
2012 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3798632/ |
| _version_ |
1612018936187977728 |