Neuropsychology, social cognition and global functioning among bipolar, schizophrenic patients and healthy controls: preliminary data

Neuropsychology, social cognition and global functioning among bipolar, schizophrenic patients and healthy controls: preliminary data

This study aimed to determine the extent of impairment in social and non-social cognitive domains in an ecological context comparing bipolar (BD), schizophrenic (SKZ) patients and healthy controls (HC). The sample was enrolled at the Department of Psychiatry of Policlinico Hospital, University of Mi...

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Main Authors: Caletti, Elisabetta, Paoli, Riccardo A., Fiorentini, Alessio, Cigliobianco, Michela, Zugno, Elisa, Serati, Marta, Orsenigo, Giulia, Grillo, Paolo, Zago, Stefano, Caldiroli, Alice, Prunas, Cecilia, Giusti, Francesca, Consonni, Dario, Altamura, A. Carlo
Format: Online
Language:English
Published: Frontiers Media S.A. 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3797996/
id pubmed-3797996
recordtype oai_dc
spelling pubmed-37979962013-10-21 Neuropsychology, social cognition and global functioning among bipolar, schizophrenic patients and healthy controls: preliminary data Caletti, Elisabetta Paoli, Riccardo A. Fiorentini, Alessio Cigliobianco, Michela Zugno, Elisa Serati, Marta Orsenigo, Giulia Grillo, Paolo Zago, Stefano Caldiroli, Alice Prunas, Cecilia Giusti, Francesca Consonni, Dario Altamura, A. Carlo Neuroscience This study aimed to determine the extent of impairment in social and non-social cognitive domains in an ecological context comparing bipolar (BD), schizophrenic (SKZ) patients and healthy controls (HC). The sample was enrolled at the Department of Psychiatry of Policlinico Hospital, University of Milan; it includes stabilized SKZ patients (n = 30), euthymic bipolar patients (n = 18) and HC (n = 18). Patients and controls completed psychiatric assessment rating scales, the Brief Assessment of Cognition in Schizophrenia (BACS) and the Executive and Social Cognition Battery (ESCB) that contains both ecological tests of executive function and social cognition, in order to better detect cognitive deficits in patients with normal results in standard executive batteries. The three groups differed significantly for gender and substance abuse, however, the differences did not influence the results. BD patients showed less impairment on cognitive performance compared to SKZ patients, even in “ecological” tests that mimic real life scenarios. In particular, BD performed better than SKZ in verbal memory (p < 0.0038) and BACS symbol coding (p < 0.0043). Regarding the ESCB tests, in the Hotel task SKZ patients completed significantly less tasks (p < 0.001), showed a greater number of errors in Multiple Errands Test (MET-HV) (p < 0.0248) and a worse performance in Theory of Mind (ToM) tests (p < 0.001 for the Eyes test and Faux pas test). Both patients' groups performed significantly worse than HC. Finally, significant differences were found between the two groups in GAF scores, being greater among BD subjects (p < 0.001). GAF was correlated with BACS and ESCB scores showing the crucial role of cognitive and ecological performances in patients' global functioning. Frontiers Media S.A. 2013-10-17 /pmc/articles/PMC3797996/ /pubmed/24146642 http://dx.doi.org/10.3389/fnhum.2013.00661 Text en Copyright © 2013 Caletti, Paoli, Fiorentini, Cigliobianco, Zugno, Serati, Orsenigo, Grillo, Consonni, Zago, Caldiroli, Prunas, Giusti and Altamura. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
repository_type Open Access Journal
institution_category Foreign Institution
institution US National Center for Biotechnology Information
building NCBI PubMed
collection Online Access
language English
format Online
author Caletti, Elisabetta
Paoli, Riccardo A.
Fiorentini, Alessio
Cigliobianco, Michela
Zugno, Elisa
Serati, Marta
Orsenigo, Giulia
Grillo, Paolo
Zago, Stefano
Caldiroli, Alice
Prunas, Cecilia
Giusti, Francesca
Consonni, Dario
Altamura, A. Carlo
spellingShingle Caletti, Elisabetta
Paoli, Riccardo A.
Fiorentini, Alessio
Cigliobianco, Michela
Zugno, Elisa
Serati, Marta
Orsenigo, Giulia
Grillo, Paolo
Zago, Stefano
Caldiroli, Alice
Prunas, Cecilia
Giusti, Francesca
Consonni, Dario
Altamura, A. Carlo
Neuropsychology, social cognition and global functioning among bipolar, schizophrenic patients and healthy controls: preliminary data
author_facet Caletti, Elisabetta
Paoli, Riccardo A.
Fiorentini, Alessio
Cigliobianco, Michela
Zugno, Elisa
Serati, Marta
Orsenigo, Giulia
Grillo, Paolo
Zago, Stefano
Caldiroli, Alice
Prunas, Cecilia
Giusti, Francesca
Consonni, Dario
Altamura, A. Carlo
author_sort Caletti, Elisabetta
title Neuropsychology, social cognition and global functioning among bipolar, schizophrenic patients and healthy controls: preliminary data
title_short Neuropsychology, social cognition and global functioning among bipolar, schizophrenic patients and healthy controls: preliminary data
title_full Neuropsychology, social cognition and global functioning among bipolar, schizophrenic patients and healthy controls: preliminary data
title_fullStr Neuropsychology, social cognition and global functioning among bipolar, schizophrenic patients and healthy controls: preliminary data
title_full_unstemmed Neuropsychology, social cognition and global functioning among bipolar, schizophrenic patients and healthy controls: preliminary data
title_sort neuropsychology, social cognition and global functioning among bipolar, schizophrenic patients and healthy controls: preliminary data
description This study aimed to determine the extent of impairment in social and non-social cognitive domains in an ecological context comparing bipolar (BD), schizophrenic (SKZ) patients and healthy controls (HC). The sample was enrolled at the Department of Psychiatry of Policlinico Hospital, University of Milan; it includes stabilized SKZ patients (n = 30), euthymic bipolar patients (n = 18) and HC (n = 18). Patients and controls completed psychiatric assessment rating scales, the Brief Assessment of Cognition in Schizophrenia (BACS) and the Executive and Social Cognition Battery (ESCB) that contains both ecological tests of executive function and social cognition, in order to better detect cognitive deficits in patients with normal results in standard executive batteries. The three groups differed significantly for gender and substance abuse, however, the differences did not influence the results. BD patients showed less impairment on cognitive performance compared to SKZ patients, even in “ecological” tests that mimic real life scenarios. In particular, BD performed better than SKZ in verbal memory (p < 0.0038) and BACS symbol coding (p < 0.0043). Regarding the ESCB tests, in the Hotel task SKZ patients completed significantly less tasks (p < 0.001), showed a greater number of errors in Multiple Errands Test (MET-HV) (p < 0.0248) and a worse performance in Theory of Mind (ToM) tests (p < 0.001 for the Eyes test and Faux pas test). Both patients' groups performed significantly worse than HC. Finally, significant differences were found between the two groups in GAF scores, being greater among BD subjects (p < 0.001). GAF was correlated with BACS and ESCB scores showing the crucial role of cognitive and ecological performances in patients' global functioning.
publisher Frontiers Media S.A.
publishDate 2013
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3797996/
_version_ 1612018709070610432

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