Back-scatter based whispering gallery mode sensing

Whispering gallery mode biosensors allow selective unlabelled detection of single proteins and, combined with quantum limited sensitivity, the possibility for noninvasive real-time observation of motor molecule motion. However, to date technical noise sources, most particularly low frequency laser n...

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Main Authors:	Knittel, Joachim, Swaim, Jon D., McAuslan, David L., Brawley, George A., Bowen, Warwick P.
Format:	Online
Language:	English
Published:	Nature Publishing Group 2013
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3797986/

id	pubmed-3797986
recordtype	oai_dc
spelling	pubmed-37979862013-10-18 Back-scatter based whispering gallery mode sensing Knittel, Joachim Swaim, Jon D. McAuslan, David L. Brawley, George A. Bowen, Warwick P. Article Whispering gallery mode biosensors allow selective unlabelled detection of single proteins and, combined with quantum limited sensitivity, the possibility for noninvasive real-time observation of motor molecule motion. However, to date technical noise sources, most particularly low frequency laser noise, have constrained such applications. Here we introduce a new technique for whispering gallery mode sensing based on direct detection of back-scattered light. This experimentally straightforward technique is immune to frequency noise in principle, and further, acts to suppress thermorefractive noise. We demonstrate 27 dB of frequency noise suppression, eliminating frequency noise as a source of sensitivity degradation and allowing an absolute frequency shift sensitivity of 76 kHz. Our results open a new pathway towards single molecule biophysics experiments and ultrasensitive biosensors. Nature Publishing Group 2013-10-17 /pmc/articles/PMC3797986/ /pubmed/24131939 http://dx.doi.org/10.1038/srep02974 Text en Copyright © 2013, Macmillan Publishers Limited. All rights reserved http://creativecommons.org/licenses/by/3.0/ This work is licensed under a Creative Commons Attribution 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by/3.0/
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Knittel, Joachim Swaim, Jon D. McAuslan, David L. Brawley, George A. Bowen, Warwick P.
spellingShingle	Knittel, Joachim Swaim, Jon D. McAuslan, David L. Brawley, George A. Bowen, Warwick P. Back-scatter based whispering gallery mode sensing
author_facet	Knittel, Joachim Swaim, Jon D. McAuslan, David L. Brawley, George A. Bowen, Warwick P.
author_sort	Knittel, Joachim
title	Back-scatter based whispering gallery mode sensing
title_short	Back-scatter based whispering gallery mode sensing
title_full	Back-scatter based whispering gallery mode sensing
title_fullStr	Back-scatter based whispering gallery mode sensing
title_full_unstemmed	Back-scatter based whispering gallery mode sensing
title_sort	back-scatter based whispering gallery mode sensing
description	Whispering gallery mode biosensors allow selective unlabelled detection of single proteins and, combined with quantum limited sensitivity, the possibility for noninvasive real-time observation of motor molecule motion. However, to date technical noise sources, most particularly low frequency laser noise, have constrained such applications. Here we introduce a new technique for whispering gallery mode sensing based on direct detection of back-scattered light. This experimentally straightforward technique is immune to frequency noise in principle, and further, acts to suppress thermorefractive noise. We demonstrate 27 dB of frequency noise suppression, eliminating frequency noise as a source of sensitivity degradation and allowing an absolute frequency shift sensitivity of 76 kHz. Our results open a new pathway towards single molecule biophysics experiments and ultrasensitive biosensors.
publisher	Nature Publishing Group
publishDate	2013
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3797986/
_version_	1612018703499526144

Back-scatter based whispering gallery mode sensing

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