Discovery of Mycobacterium tuberculosis Protein Tyrosine Phosphatase B (PtpB) Inhibitors from Natural Products

Discovery of Mycobacterium tuberculosis Protein Tyrosine Phosphatase B (PtpB) Inhibitors from Natural Products

Protein tyrosine phosphatase B (PtpB) is one of the virulence factors secreted into the host cell by Mycobacterium tuberculosis. PtpB attenuates host immune defenses by interfering with signal transduction pathways in macrophages and, therefore, it is considered a promising target for the developmen...

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Bibliographic Details
Main Authors: Mascarello, Alessandra, Mori, Mattia, Chiaradia-Delatorre, Louise Domeneghini, Menegatti, Angela Camila Orbem, Monache, Franco Delle, Ferrari, Franco, Yunes, Rosendo Augusto, Nunes, Ricardo José, Terenzi, Hernán, Botta, Bruno, Botta, Maurizio
Format: Online
Language:English
Published: Public Library of Science 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3796549/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3796549/

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