Loss of DAP12 and FcRγ Drives Exaggerated IL-12 Production and CD8+ T Cell Response by CCR2+ Mo-DCs

Loss of DAP12 and FcRγ Drives Exaggerated IL-12 Production and CD8+ T Cell Response by CCR2+ Mo-DCs

Dap12 and FcRγ, the two transmembrane ITAM-containing signaling adaptors expressed in dendritic cells (DC), are implicated in the regulation of DC function. Several activating and adhesion receptors including integrins require these chains for their function in triggering downstream signaling and ef...

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Bibliographic Details
Main Authors: Gmyrek, Grzegorz B., Akilesh, Holly M., Graham, Daniel B., Fuchs, Anja, Yang, Lihua, Miller, Mark J., Sandoval, Gabriel J., Sheehan, Kathleen C. F., Schreiber, Robert D., Diamond, Michael S., Swat, Wojciech
Format: Online
Language:English
Published: Public Library of Science 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3796521/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3796521/

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