Separating lexical-semantic access from other mnemonic processes in picture-name verification

We present a novel paradigm to identify shared and unique brain regions underlying non-semantic, non-phonological, abstract, audio-visual (AV) memory vs. naming using a longitudinal functional magnetic resonance imaging experiment. Participants were trained to associate novel AV stimulus pairs conta...

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Main Authors:	Smith, Jason F., Braun, Allen R., Alexander, Gene E., Chen, Kewei, Horwitz, Barry
Format:	Online
Language:	English
Published:	Frontiers Media S.A. 2013
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3795327/

id	pubmed-3795327
recordtype	oai_dc
spelling	pubmed-37953272013-10-15 Separating lexical-semantic access from other mnemonic processes in picture-name verification Smith, Jason F. Braun, Allen R. Alexander, Gene E. Chen, Kewei Horwitz, Barry Psychology We present a novel paradigm to identify shared and unique brain regions underlying non-semantic, non-phonological, abstract, audio-visual (AV) memory vs. naming using a longitudinal functional magnetic resonance imaging experiment. Participants were trained to associate novel AV stimulus pairs containing hidden linguistic content. Half of the stimulus pairs were distorted images of animals and sine-wave speech versions of the animal's name. Images and sounds were distorted in such a way as to make their linguistic content easily recognizable only after being made aware of its existence. Memory for the pairings was tested by presenting an AV pair and asking participants to verify if the two stimuli formed a learned pairing. After memory testing, the hidden linguistic content was revealed and participants were tested again on their recollection of the pairings in this linguistically informed state. Once informed, the AV verification task could be performed by naming the picture. There was substantial overlap between the regions involved in recognition of non-linguistic sensory memory and naming, suggesting a strong relation between them. Contrasts between sessions identified left angular gyrus and middle temporal gyrus as key additional players in the naming network. Left inferior frontal regions participated in both naming and non-linguistic AV memory suggesting the region is responsible for AV memory independent of phonological content contrary to previous proposals. Functional connectivity between angular gyrus and left inferior frontal gyrus and left middle temporal gyrus increased when performing the AV task as naming. The results are consistent with the hypothesis that, at the spatial resolution of fMRI, the regions that facilitate non-linguistic AV associations are a subset of those that facilitate naming though reorganized into distinct networks. Frontiers Media S.A. 2013-10-11 /pmc/articles/PMC3795327/ /pubmed/24130539 http://dx.doi.org/10.3389/fpsyg.2013.00706 Text en Copyright © 2013 Smith, Braun, Alexander, Chen and Horwitz. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Smith, Jason F. Braun, Allen R. Alexander, Gene E. Chen, Kewei Horwitz, Barry
spellingShingle	Smith, Jason F. Braun, Allen R. Alexander, Gene E. Chen, Kewei Horwitz, Barry Separating lexical-semantic access from other mnemonic processes in picture-name verification
author_facet	Smith, Jason F. Braun, Allen R. Alexander, Gene E. Chen, Kewei Horwitz, Barry
author_sort	Smith, Jason F.
title	Separating lexical-semantic access from other mnemonic processes in picture-name verification
title_short	Separating lexical-semantic access from other mnemonic processes in picture-name verification
title_full	Separating lexical-semantic access from other mnemonic processes in picture-name verification
title_fullStr	Separating lexical-semantic access from other mnemonic processes in picture-name verification
title_full_unstemmed	Separating lexical-semantic access from other mnemonic processes in picture-name verification
title_sort	separating lexical-semantic access from other mnemonic processes in picture-name verification
description	We present a novel paradigm to identify shared and unique brain regions underlying non-semantic, non-phonological, abstract, audio-visual (AV) memory vs. naming using a longitudinal functional magnetic resonance imaging experiment. Participants were trained to associate novel AV stimulus pairs containing hidden linguistic content. Half of the stimulus pairs were distorted images of animals and sine-wave speech versions of the animal's name. Images and sounds were distorted in such a way as to make their linguistic content easily recognizable only after being made aware of its existence. Memory for the pairings was tested by presenting an AV pair and asking participants to verify if the two stimuli formed a learned pairing. After memory testing, the hidden linguistic content was revealed and participants were tested again on their recollection of the pairings in this linguistically informed state. Once informed, the AV verification task could be performed by naming the picture. There was substantial overlap between the regions involved in recognition of non-linguistic sensory memory and naming, suggesting a strong relation between them. Contrasts between sessions identified left angular gyrus and middle temporal gyrus as key additional players in the naming network. Left inferior frontal regions participated in both naming and non-linguistic AV memory suggesting the region is responsible for AV memory independent of phonological content contrary to previous proposals. Functional connectivity between angular gyrus and left inferior frontal gyrus and left middle temporal gyrus increased when performing the AV task as naming. The results are consistent with the hypothesis that, at the spatial resolution of fMRI, the regions that facilitate non-linguistic AV associations are a subset of those that facilitate naming though reorganized into distinct networks.
publisher	Frontiers Media S.A.
publishDate	2013
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3795327/
_version_	1612017902392705024

Separating lexical-semantic access from other mnemonic processes in picture-name verification

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