Seroepidemiologic Survey of Epidemic Cholera in Haiti to Assess Spectrum of Illness and Risk Factors for Severe Disease
To assess the spectrum of illness from toxigenic Vibrio cholerae O1 and risk factors for severe cholera in Haiti, we conducted a cross-sectional survey in a rural commune with more than 21,000 residents. During March 22–April 6, 2011, we interviewed 2,622 residents ≥ 2 years of age and tested serum...
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The American Society of Tropical Medicine and Hygiene
2013
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3795095/ |
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pubmed-37950952013-11-04 Seroepidemiologic Survey of Epidemic Cholera in Haiti to Assess Spectrum of Illness and Risk Factors for Severe Disease Jackson, Brendan R. Talkington, Deborah F. Pruckler, James M. Fouché, M. D. Bernadette Lafosse, Elsie Nygren, Benjamin Gómez, Gerardo A. Dahourou, Georges A. Archer, W. Roodly Payne, Amanda B. Hooper, W. Craig Tappero, Jordan W. Derado, Gordana Magloire, Roc Gerner-Smidt, Peter Freeman, Nicole Boncy, Jacques Mintz, Eric D. AJTMH and PAHO: Commemorating the 3rd Anniversary of the Cholera Outbreak in Haiti: Invited Papers To assess the spectrum of illness from toxigenic Vibrio cholerae O1 and risk factors for severe cholera in Haiti, we conducted a cross-sectional survey in a rural commune with more than 21,000 residents. During March 22–April 6, 2011, we interviewed 2,622 residents ≥ 2 years of age and tested serum specimens from 2,527 (96%) participants for vibriocidal and antibodies against cholera toxin; 18% of participants reported a cholera diagnosis, 39% had vibriocidal titers ≥ 320, and 64% had vibriocidal titers ≥ 80, suggesting widespread infection. Among seropositive participants (vibriocidal titers ≥ 320), 74.5% reported no diarrhea and 9.0% had severe cholera (reported receiving intravenous fluids and overnight hospitalization). This high burden of severe cholera is likely explained by the lack of pre-existing immunity in this population, although the virulence of the atypical El Tor strain causing the epidemic and other factors might also play a role. The American Society of Tropical Medicine and Hygiene 2013-10-09 /pmc/articles/PMC3795095/ /pubmed/24106192 http://dx.doi.org/10.4269/ajtmh.13-0208 Text en ©The American Society of Tropical Medicine and Hygiene This is an Open Access article distributed under the terms of the American Society of Tropical Medicine and Hygiene's Re-use License which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Jackson, Brendan R. Talkington, Deborah F. Pruckler, James M. Fouché, M. D. Bernadette Lafosse, Elsie Nygren, Benjamin Gómez, Gerardo A. Dahourou, Georges A. Archer, W. Roodly Payne, Amanda B. Hooper, W. Craig Tappero, Jordan W. Derado, Gordana Magloire, Roc Gerner-Smidt, Peter Freeman, Nicole Boncy, Jacques Mintz, Eric D. |
| spellingShingle |
Jackson, Brendan R. Talkington, Deborah F. Pruckler, James M. Fouché, M. D. Bernadette Lafosse, Elsie Nygren, Benjamin Gómez, Gerardo A. Dahourou, Georges A. Archer, W. Roodly Payne, Amanda B. Hooper, W. Craig Tappero, Jordan W. Derado, Gordana Magloire, Roc Gerner-Smidt, Peter Freeman, Nicole Boncy, Jacques Mintz, Eric D. Seroepidemiologic Survey of Epidemic Cholera in Haiti to Assess Spectrum of Illness and Risk Factors for Severe Disease |
| author_facet |
Jackson, Brendan R. Talkington, Deborah F. Pruckler, James M. Fouché, M. D. Bernadette Lafosse, Elsie Nygren, Benjamin Gómez, Gerardo A. Dahourou, Georges A. Archer, W. Roodly Payne, Amanda B. Hooper, W. Craig Tappero, Jordan W. Derado, Gordana Magloire, Roc Gerner-Smidt, Peter Freeman, Nicole Boncy, Jacques Mintz, Eric D. |
| author_sort |
Jackson, Brendan R. |
| title |
Seroepidemiologic Survey of Epidemic Cholera in Haiti to Assess Spectrum of Illness and Risk Factors for Severe Disease |
| title_short |
Seroepidemiologic Survey of Epidemic Cholera in Haiti to Assess Spectrum of Illness and Risk Factors for Severe Disease |
| title_full |
Seroepidemiologic Survey of Epidemic Cholera in Haiti to Assess Spectrum of Illness and Risk Factors for Severe Disease |
| title_fullStr |
Seroepidemiologic Survey of Epidemic Cholera in Haiti to Assess Spectrum of Illness and Risk Factors for Severe Disease |
| title_full_unstemmed |
Seroepidemiologic Survey of Epidemic Cholera in Haiti to Assess Spectrum of Illness and Risk Factors for Severe Disease |
| title_sort |
seroepidemiologic survey of epidemic cholera in haiti to assess spectrum of illness and risk factors for severe disease |
| description |
To assess the spectrum of illness from toxigenic Vibrio cholerae O1 and risk factors for severe cholera in Haiti, we conducted a cross-sectional survey in a rural commune with more than 21,000 residents. During March 22–April 6, 2011, we interviewed 2,622 residents ≥ 2 years of age and tested serum specimens from 2,527 (96%) participants for vibriocidal and antibodies against cholera toxin; 18% of participants reported a cholera diagnosis, 39% had vibriocidal titers ≥ 320, and 64% had vibriocidal titers ≥ 80, suggesting widespread infection. Among seropositive participants (vibriocidal titers ≥ 320), 74.5% reported no diarrhea and 9.0% had severe cholera (reported receiving intravenous fluids and overnight hospitalization). This high burden of severe cholera is likely explained by the lack of pre-existing immunity in this population, although the virulence of the atypical El Tor strain causing the epidemic and other factors might also play a role. |
| publisher |
The American Society of Tropical Medicine and Hygiene |
| publishDate |
2013 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3795095/ |
| _version_ |
1612017842952077312 |