Novel Strategies for the Prevention and Treatment of Biofilm Related Infections
Biofilm formation by human bacterial pathogens on implanted medical devices causes major morbidity and mortality among patients, and leads to billions of dollars in healthcare cost. Biofilm is a complex bacterial community that is highly resistant to antibiotics and human immunity. As a result, nove...
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| Format: | Online |
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MDPI
2013
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3794791/ |
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pubmed-37947912013-10-21 Novel Strategies for the Prevention and Treatment of Biofilm Related Infections Chen, Meng Yu, Qingsong Sun, Hongmin Review Biofilm formation by human bacterial pathogens on implanted medical devices causes major morbidity and mortality among patients, and leads to billions of dollars in healthcare cost. Biofilm is a complex bacterial community that is highly resistant to antibiotics and human immunity. As a result, novel therapeutic solutions other than the conventional antibiotic therapies are in urgent need. In this review, we will discuss the recent research in discovery of alternative approaches to prevent or treat biofilms. Current anti-biofilm technologies could be divided into two groups. The first group focuses on targeting the biofilm forming process of bacteria based on our understanding of the molecular mechanism of biofilm formation. Small molecules and enzymes have been developed to inhibit or disrupt biofilm formation. Another group of anti-biofilm technologies focuses on modifying the biomaterials used in medical devices to make them resistant to biofilm formation. While these novel anti-biofilm approaches are still in nascent phases of development, efforts devoted to these technologies could eventually lead to anti-biofilm therapies that are superior to the current antibiotic treatment. MDPI 2013-09-06 /pmc/articles/PMC3794791/ /pubmed/24018891 http://dx.doi.org/10.3390/ijms140918488 Text en © 2013 by the authors; licensee MDPI, Basel, Switzerland http://creativecommons.org/licenses/by/3.0 This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Chen, Meng Yu, Qingsong Sun, Hongmin |
| spellingShingle |
Chen, Meng Yu, Qingsong Sun, Hongmin Novel Strategies for the Prevention and Treatment of Biofilm Related Infections |
| author_facet |
Chen, Meng Yu, Qingsong Sun, Hongmin |
| author_sort |
Chen, Meng |
| title |
Novel Strategies for the Prevention and Treatment of Biofilm Related Infections |
| title_short |
Novel Strategies for the Prevention and Treatment of Biofilm Related Infections |
| title_full |
Novel Strategies for the Prevention and Treatment of Biofilm Related Infections |
| title_fullStr |
Novel Strategies for the Prevention and Treatment of Biofilm Related Infections |
| title_full_unstemmed |
Novel Strategies for the Prevention and Treatment of Biofilm Related Infections |
| title_sort |
novel strategies for the prevention and treatment of biofilm related infections |
| description |
Biofilm formation by human bacterial pathogens on implanted medical devices causes major morbidity and mortality among patients, and leads to billions of dollars in healthcare cost. Biofilm is a complex bacterial community that is highly resistant to antibiotics and human immunity. As a result, novel therapeutic solutions other than the conventional antibiotic therapies are in urgent need. In this review, we will discuss the recent research in discovery of alternative approaches to prevent or treat biofilms. Current anti-biofilm technologies could be divided into two groups. The first group focuses on targeting the biofilm forming process of bacteria based on our understanding of the molecular mechanism of biofilm formation. Small molecules and enzymes have been developed to inhibit or disrupt biofilm formation. Another group of anti-biofilm technologies focuses on modifying the biomaterials used in medical devices to make them resistant to biofilm formation. While these novel anti-biofilm approaches are still in nascent phases of development, efforts devoted to these technologies could eventually lead to anti-biofilm therapies that are superior to the current antibiotic treatment. |
| publisher |
MDPI |
| publishDate |
2013 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3794791/ |
| _version_ |
1612017675066671104 |