Imprinting of Molecular Recognition Sites on Nanostructures and Its Applications in Chemosensors

Biological receptors including enzymes, antibodies and active proteins have been widely used as the detection platform in a variety of chemo/biosensors and bioassays. However, the use of artificial host materials in chemical/biological detections has become increasingly attractive, because the synth...

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Main Authors:	Guan, Guijian, Liu, Bianhua, Wang, Zhenyang, Zhang, Zhongping
Format:	Online
Language:	English
Published:	Molecular Diversity Preservation International (MDPI) 2008
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3791020/

id	pubmed-3791020
recordtype	oai_dc
spelling	pubmed-37910202013-10-18 Imprinting of Molecular Recognition Sites on Nanostructures and Its Applications in Chemosensors Guan, Guijian Liu, Bianhua Wang, Zhenyang Zhang, Zhongping Review Biological receptors including enzymes, antibodies and active proteins have been widely used as the detection platform in a variety of chemo/biosensors and bioassays. However, the use of artificial host materials in chemical/biological detections has become increasingly attractive, because the synthetic recognition systems such as molecularly imprinted polymers (MIPs) usually have lower costs, higher physical/chemical stability, easier preparation and better engineering possibility than biological receptors. Molecular imprinting is one of the most efficient strategies to offer a synthetic route to artificial recognition systems by a template polymerization technique, and has attracted considerable efforts due to its importance in separation, chemo/biosensors, catalysis and biomedicine. Despite the fact that MIPs have molecular recognition ability similar to that of biological receptors, traditional bulky MIP materials usually exhibit a low binding capacity and slow binding kinetics to the target species. Moreover, the MIP materials lack the signal-output response to analyte binding events when used as recognition elements in chemo/biosensors or bioassays. Recently, various explorations have demonstrated that molecular imprinting nanotechniques may provide a potential solution to these difficulties. Many successful examples of the development of MIP-based sensors have also been reported during the past several decades. This review will begin with a brief introduction to the principle of molecular imprinting nanotechnology, and then mainly summarize various synthesis methodologies and recognition properties of MIP nanomaterials and their applications in MIP-based chemosensors. Finally, the future perspectives and efforts in MIP nanomaterials and MIP-based sensors are given. Molecular Diversity Preservation International (MDPI) 2008-12-15 /pmc/articles/PMC3791020/ /pubmed/27873989 http://dx.doi.org/10.3390/s8128291 Text en © by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland. This article is an open-access article distributed under the terms and conditions of the Creative CommonsAttribution license (http://creativecommons.org/licenses/by/3.0/).
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Guan, Guijian Liu, Bianhua Wang, Zhenyang Zhang, Zhongping
spellingShingle	Guan, Guijian Liu, Bianhua Wang, Zhenyang Zhang, Zhongping Imprinting of Molecular Recognition Sites on Nanostructures and Its Applications in Chemosensors
author_facet	Guan, Guijian Liu, Bianhua Wang, Zhenyang Zhang, Zhongping
author_sort	Guan, Guijian
title	Imprinting of Molecular Recognition Sites on Nanostructures and Its Applications in Chemosensors
title_short	Imprinting of Molecular Recognition Sites on Nanostructures and Its Applications in Chemosensors
title_full	Imprinting of Molecular Recognition Sites on Nanostructures and Its Applications in Chemosensors
title_fullStr	Imprinting of Molecular Recognition Sites on Nanostructures and Its Applications in Chemosensors
title_full_unstemmed	Imprinting of Molecular Recognition Sites on Nanostructures and Its Applications in Chemosensors
title_sort	imprinting of molecular recognition sites on nanostructures and its applications in chemosensors
description	Biological receptors including enzymes, antibodies and active proteins have been widely used as the detection platform in a variety of chemo/biosensors and bioassays. However, the use of artificial host materials in chemical/biological detections has become increasingly attractive, because the synthetic recognition systems such as molecularly imprinted polymers (MIPs) usually have lower costs, higher physical/chemical stability, easier preparation and better engineering possibility than biological receptors. Molecular imprinting is one of the most efficient strategies to offer a synthetic route to artificial recognition systems by a template polymerization technique, and has attracted considerable efforts due to its importance in separation, chemo/biosensors, catalysis and biomedicine. Despite the fact that MIPs have molecular recognition ability similar to that of biological receptors, traditional bulky MIP materials usually exhibit a low binding capacity and slow binding kinetics to the target species. Moreover, the MIP materials lack the signal-output response to analyte binding events when used as recognition elements in chemo/biosensors or bioassays. Recently, various explorations have demonstrated that molecular imprinting nanotechniques may provide a potential solution to these difficulties. Many successful examples of the development of MIP-based sensors have also been reported during the past several decades. This review will begin with a brief introduction to the principle of molecular imprinting nanotechnology, and then mainly summarize various synthesis methodologies and recognition properties of MIP nanomaterials and their applications in MIP-based chemosensors. Finally, the future perspectives and efforts in MIP nanomaterials and MIP-based sensors are given.
publisher	Molecular Diversity Preservation International (MDPI)
publishDate	2008
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3791020/
_version_	1612016548806918144

Imprinting of Molecular Recognition Sites on Nanostructures and Its Applications in Chemosensors

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