Both Enhanced Biocompatibility and Antibacterial Activity in Ag-Decorated TiO2 Nanotubes

In this study, Ag is electron-beam evaporated to modify the topography of anodic TiO2 nanotubes of different diameters to obtain an implant with enhanced antibacterial activity and biocompatibility. We found that highly hydrophilic as-grown TiO2 nanotubes became poorly hydrophilic with Ag incorporat...

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Main Authors:	Lan, Ming-Ying, Liu, Chia-Pei, Huang, Her-Hsiung, Lee, Sheng-Wei
Format:	Online
Language:	English
Published:	Public Library of Science 2013
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3790793/

id	pubmed-3790793
recordtype	oai_dc
spelling	pubmed-37907932013-10-11 Both Enhanced Biocompatibility and Antibacterial Activity in Ag-Decorated TiO2 Nanotubes Lan, Ming-Ying Liu, Chia-Pei Huang, Her-Hsiung Lee, Sheng-Wei Research Article In this study, Ag is electron-beam evaporated to modify the topography of anodic TiO2 nanotubes of different diameters to obtain an implant with enhanced antibacterial activity and biocompatibility. We found that highly hydrophilic as-grown TiO2 nanotubes became poorly hydrophilic with Ag incorporation; however they could effectively recover their wettability to some extent under ultraviolet light irradiation. The results obtained from antibacterial tests suggested that the Ag-decorated TiO2 nanotubes could greatly inhibit the growth of Staphylococcus aureus. In vitro biocompatibility evaluation indicated that fibroblast cells exhibited an obvious diameter-dependent behavior on both as-grown and Ag-decorated TiO2 nanotubes. Most importantly, of all samples, the smallest diameter (25-nm-diameter) Ag-decorated nanotubes exhibited the most obvious biological activity in promoting adhesion and proliferation of human fibroblasts, and this activity could be attributed to the highly irregular topography on a nanometric scale of the Ag-decorated nanotube surface. These experimental results demonstrate that by properly controlling the structural parameters of Ag-decorated TiO2 nanotubes, an implant surface can be produced that enhances biocompatibility and simultaneously boosts antibacterial activity. Public Library of Science 2013-10-04 /pmc/articles/PMC3790793/ /pubmed/24124484 http://dx.doi.org/10.1371/journal.pone.0075364 Text en © 2013 Lan et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Lan, Ming-Ying Liu, Chia-Pei Huang, Her-Hsiung Lee, Sheng-Wei
spellingShingle	Lan, Ming-Ying Liu, Chia-Pei Huang, Her-Hsiung Lee, Sheng-Wei Both Enhanced Biocompatibility and Antibacterial Activity in Ag-Decorated TiO2 Nanotubes
author_facet	Lan, Ming-Ying Liu, Chia-Pei Huang, Her-Hsiung Lee, Sheng-Wei
author_sort	Lan, Ming-Ying
title	Both Enhanced Biocompatibility and Antibacterial Activity in Ag-Decorated TiO2 Nanotubes
title_short	Both Enhanced Biocompatibility and Antibacterial Activity in Ag-Decorated TiO2 Nanotubes
title_full	Both Enhanced Biocompatibility and Antibacterial Activity in Ag-Decorated TiO2 Nanotubes
title_fullStr	Both Enhanced Biocompatibility and Antibacterial Activity in Ag-Decorated TiO2 Nanotubes
title_full_unstemmed	Both Enhanced Biocompatibility and Antibacterial Activity in Ag-Decorated TiO2 Nanotubes
title_sort	both enhanced biocompatibility and antibacterial activity in ag-decorated tio2 nanotubes
description	In this study, Ag is electron-beam evaporated to modify the topography of anodic TiO2 nanotubes of different diameters to obtain an implant with enhanced antibacterial activity and biocompatibility. We found that highly hydrophilic as-grown TiO2 nanotubes became poorly hydrophilic with Ag incorporation; however they could effectively recover their wettability to some extent under ultraviolet light irradiation. The results obtained from antibacterial tests suggested that the Ag-decorated TiO2 nanotubes could greatly inhibit the growth of Staphylococcus aureus. In vitro biocompatibility evaluation indicated that fibroblast cells exhibited an obvious diameter-dependent behavior on both as-grown and Ag-decorated TiO2 nanotubes. Most importantly, of all samples, the smallest diameter (25-nm-diameter) Ag-decorated nanotubes exhibited the most obvious biological activity in promoting adhesion and proliferation of human fibroblasts, and this activity could be attributed to the highly irregular topography on a nanometric scale of the Ag-decorated nanotube surface. These experimental results demonstrate that by properly controlling the structural parameters of Ag-decorated TiO2 nanotubes, an implant surface can be produced that enhances biocompatibility and simultaneously boosts antibacterial activity.
publisher	Public Library of Science
publishDate	2013
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3790793/
_version_	1612016452271865856

Both Enhanced Biocompatibility and Antibacterial Activity in Ag-Decorated TiO2 Nanotubes

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