Regulation of Mammalian Autophagy by Class II and III PI 3-Kinases through PI3P Synthesis

Regulation of Mammalian Autophagy by Class II and III PI 3-Kinases through PI3P Synthesis

Synthesis of phosphatidylinositol-3-phosphate (PI3P) by Vps34, a class III phosphatidylinositol 3-kinase (PI3K), is critical for the initial steps of autophagosome (AP) biogenesis. Although Vps34 is the sole source of PI3P in budding yeast, mammalian cells can produce PI3P through alternate pathways...

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Bibliographic Details
Main Authors: Devereaux, Kelly, Dall’Armi, Claudia, Alcazar-Roman, Abel, Ogasawara, Yuta, Zhou, Xiang, Wang, Fan, Yamamoto, Akitsugu, De Camilli, Pietro, Di Paolo, Gilbert
Format: Online
Language:English
Published: Public Library of Science 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3789715/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3789715/

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