Deficits in latent inhibition induced by estradiol replacement are ameliorated by haloperidol treatment

There are sex differences in the symptomatology of schizophrenia, and in the response to antipsychotic treatments. One hallmark symptom of schizophrenia is a deficit in selective attention. Selective attention can be measured using a latent inhibition (LI) paradigm in humans; LI can be measured in r...

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Main Authors:	Almey, Anne, Hafez, Nada M., Hantson, Arne, Brake, Wayne G.
Format:	Online
Language:	English
Published:	Frontiers Media S.A. 2013
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3787244/

id	pubmed-3787244
recordtype	oai_dc
spelling	pubmed-37872442013-10-07 Deficits in latent inhibition induced by estradiol replacement are ameliorated by haloperidol treatment Almey, Anne Hafez, Nada M. Hantson, Arne Brake, Wayne G. Neuroscience There are sex differences in the symptomatology of schizophrenia, and in the response to antipsychotic treatments. One hallmark symptom of schizophrenia is a deficit in selective attention. Selective attention can be measured using a latent inhibition (LI) paradigm in humans; LI can be measured in rodents, and is used as an animal model of the selective attention deficits observed in schizophrenia. In the current experiments LI was used to clarify whether selective attention differs between male rats and ovariectomized (OVX) female rats receiving different estradiol (E2) replacement regimens. An additional aim was to determine whether haloperidol’s (HAL) facilitation of LI is enhanced by E2. Males and OVX female rats were trained in a conditioned emotional response LI paradigm. Females received no E2 replacement, a chronic low dose of E2 via silastic capsule, or a high phasic dose of E2 via silastic capsule accompanied by E2 (10 µg/kg subcutaneous (SC)) injections every 4th day. Actual plasma levels of E2 were determined using an enzyme linked immunosorbent assay. Rats were also administered a vehicle treatment, a 0.05 mg/kg, or a 0.1 mg/kg IP injection of HAL. Males and OVX females that did not receive E2 replacement both exhibited LI, but LI was not observed in the low and high E2 replacement groups. HAL restored LI at a lower dose in the females receiving high E2 replacement compared to females receiving low E2 replacement, indicating that E2 replacement facilitates HAL in restoring LI. Frontiers Media S.A. 2013-10-01 /pmc/articles/PMC3787244/ /pubmed/24101897 http://dx.doi.org/10.3389/fnbeh.2013.00136 Text en Copyright © 2013 Almey, Hafez, Hantson and Brake. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Almey, Anne Hafez, Nada M. Hantson, Arne Brake, Wayne G.
spellingShingle	Almey, Anne Hafez, Nada M. Hantson, Arne Brake, Wayne G. Deficits in latent inhibition induced by estradiol replacement are ameliorated by haloperidol treatment
author_facet	Almey, Anne Hafez, Nada M. Hantson, Arne Brake, Wayne G.
author_sort	Almey, Anne
title	Deficits in latent inhibition induced by estradiol replacement are ameliorated by haloperidol treatment
title_short	Deficits in latent inhibition induced by estradiol replacement are ameliorated by haloperidol treatment
title_full	Deficits in latent inhibition induced by estradiol replacement are ameliorated by haloperidol treatment
title_fullStr	Deficits in latent inhibition induced by estradiol replacement are ameliorated by haloperidol treatment
title_full_unstemmed	Deficits in latent inhibition induced by estradiol replacement are ameliorated by haloperidol treatment
title_sort	deficits in latent inhibition induced by estradiol replacement are ameliorated by haloperidol treatment
description	There are sex differences in the symptomatology of schizophrenia, and in the response to antipsychotic treatments. One hallmark symptom of schizophrenia is a deficit in selective attention. Selective attention can be measured using a latent inhibition (LI) paradigm in humans; LI can be measured in rodents, and is used as an animal model of the selective attention deficits observed in schizophrenia. In the current experiments LI was used to clarify whether selective attention differs between male rats and ovariectomized (OVX) female rats receiving different estradiol (E2) replacement regimens. An additional aim was to determine whether haloperidol’s (HAL) facilitation of LI is enhanced by E2. Males and OVX female rats were trained in a conditioned emotional response LI paradigm. Females received no E2 replacement, a chronic low dose of E2 via silastic capsule, or a high phasic dose of E2 via silastic capsule accompanied by E2 (10 µg/kg subcutaneous (SC)) injections every 4th day. Actual plasma levels of E2 were determined using an enzyme linked immunosorbent assay. Rats were also administered a vehicle treatment, a 0.05 mg/kg, or a 0.1 mg/kg IP injection of HAL. Males and OVX females that did not receive E2 replacement both exhibited LI, but LI was not observed in the low and high E2 replacement groups. HAL restored LI at a lower dose in the females receiving high E2 replacement compared to females receiving low E2 replacement, indicating that E2 replacement facilitates HAL in restoring LI.
publisher	Frontiers Media S.A.
publishDate	2013
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3787244/
_version_	1612015341464977408

Deficits in latent inhibition induced by estradiol replacement are ameliorated by haloperidol treatment

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