GARP Is Regulated by miRNAs and Controls Latent TGF-β1 Production by Human Regulatory T Cells

GARP Is Regulated by miRNAs and Controls Latent TGF-β1 Production by Human Regulatory T Cells

GARP is a transmembrane protein present on stimulated human regulatory T lymphocytes (Tregs), but not on other T lymphocytes (Th cells). It presents the latent form of TGF-β1 on the Treg surface. We report here that GARP favors the cleavage of the pro-TGF-β1 precursor and increases the amount of sec...

Full description

Bibliographic Details
Main Authors: Gauthy, Emilie, Cuende, Julia, Stockis, Julie, Huygens, Caroline, Lethé, Bernard, Collet, Jean-François, Bommer, Guido, Coulie, Pierre G., Lucas, Sophie
Format: Online
Language:English
Published: Public Library of Science 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3787020/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3787020/

Similar Items