Low Serum Concentration of Obestatin as a Predictor of Mortality in Maintenance Hemodialysis Patients

Obestatin, a proposed anorexigenic gut hormone, has been shown to have a number of beneficial cardiotropic effects in experimental studies. We hypothesized that obestatin alteration in hemodialysis patients may link to clinical outcomes. This cross-sectional study with prospective followup for almos...

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Main Authors:	Beberashvili, Ilia, Sinuani, Inna, Azar, Ada, Kadoshi, Hadas, Shapiro, Gregory, Feldman, Leonid, Sandbank, Judith, Averbukh, Zhan
Format:	Online
Language:	English
Published:	Hindawi Publishing Corporation 2013
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3786512/

id	pubmed-3786512
recordtype	oai_dc
spelling	pubmed-37865122013-10-07 Low Serum Concentration of Obestatin as a Predictor of Mortality in Maintenance Hemodialysis Patients Beberashvili, Ilia Sinuani, Inna Azar, Ada Kadoshi, Hadas Shapiro, Gregory Feldman, Leonid Sandbank, Judith Averbukh, Zhan Clinical Study Obestatin, a proposed anorexigenic gut hormone, has been shown to have a number of beneficial cardiotropic effects in experimental studies. We hypothesized that obestatin alteration in hemodialysis patients may link to clinical outcomes. This cross-sectional study with prospective followup for almost 4 years was performed on 94 prevalent hemodialysis patients. Obestatin, leptin, proinflammatory cytokines (tumor necrosis factor-α [TNF-α], interleukin-6, and various nutritional markers were measured. Patients with low obestatin levels, defined as a level less than median, had a worse all-cause mortality and cardiovascular mortality. The crude all-cause (HR 2.23, 95% CI 1.17 to 4.24) and cardiovascular mortality hazard ratios (HR 4.03, 95% CI 1.27 to 12.76) in these patients continued to be significant after adjustment for various confounders for all-cause mortality. Across the four obestatin-TNF-α categories, the group with low obestatin and high TNF-α (above median level) exhibited a worse outcome in both all-cause mortality and cardiovascular mortality. Clinical characteristics of patients in low obestatin high TNF-α group did not differ from other obestatin-TNF-α categorized groups. In summary, low serum obestatin concentration is an independent predictor of mortality in prevalent hemodialysis patients. Novel interactions were observed between obestatin and TNF-α, which were associated with mortality risk, especially those due to cardiovascular causes. Hindawi Publishing Corporation 2013 2013-09-12 /pmc/articles/PMC3786512/ /pubmed/24102059 http://dx.doi.org/10.1155/2013/796586 Text en Copyright © 2013 Ilia Beberashvili et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Beberashvili, Ilia Sinuani, Inna Azar, Ada Kadoshi, Hadas Shapiro, Gregory Feldman, Leonid Sandbank, Judith Averbukh, Zhan
spellingShingle	Beberashvili, Ilia Sinuani, Inna Azar, Ada Kadoshi, Hadas Shapiro, Gregory Feldman, Leonid Sandbank, Judith Averbukh, Zhan Low Serum Concentration of Obestatin as a Predictor of Mortality in Maintenance Hemodialysis Patients
author_facet	Beberashvili, Ilia Sinuani, Inna Azar, Ada Kadoshi, Hadas Shapiro, Gregory Feldman, Leonid Sandbank, Judith Averbukh, Zhan
author_sort	Beberashvili, Ilia
title	Low Serum Concentration of Obestatin as a Predictor of Mortality in Maintenance Hemodialysis Patients
title_short	Low Serum Concentration of Obestatin as a Predictor of Mortality in Maintenance Hemodialysis Patients
title_full	Low Serum Concentration of Obestatin as a Predictor of Mortality in Maintenance Hemodialysis Patients
title_fullStr	Low Serum Concentration of Obestatin as a Predictor of Mortality in Maintenance Hemodialysis Patients
title_full_unstemmed	Low Serum Concentration of Obestatin as a Predictor of Mortality in Maintenance Hemodialysis Patients
title_sort	low serum concentration of obestatin as a predictor of mortality in maintenance hemodialysis patients
description	Obestatin, a proposed anorexigenic gut hormone, has been shown to have a number of beneficial cardiotropic effects in experimental studies. We hypothesized that obestatin alteration in hemodialysis patients may link to clinical outcomes. This cross-sectional study with prospective followup for almost 4 years was performed on 94 prevalent hemodialysis patients. Obestatin, leptin, proinflammatory cytokines (tumor necrosis factor-α [TNF-α], interleukin-6, and various nutritional markers were measured. Patients with low obestatin levels, defined as a level less than median, had a worse all-cause mortality and cardiovascular mortality. The crude all-cause (HR 2.23, 95% CI 1.17 to 4.24) and cardiovascular mortality hazard ratios (HR 4.03, 95% CI 1.27 to 12.76) in these patients continued to be significant after adjustment for various confounders for all-cause mortality. Across the four obestatin-TNF-α categories, the group with low obestatin and high TNF-α (above median level) exhibited a worse outcome in both all-cause mortality and cardiovascular mortality. Clinical characteristics of patients in low obestatin high TNF-α group did not differ from other obestatin-TNF-α categorized groups. In summary, low serum obestatin concentration is an independent predictor of mortality in prevalent hemodialysis patients. Novel interactions were observed between obestatin and TNF-α, which were associated with mortality risk, especially those due to cardiovascular causes.
publisher	Hindawi Publishing Corporation
publishDate	2013
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3786512/
_version_	1612015107632529408

Low Serum Concentration of Obestatin as a Predictor of Mortality in Maintenance Hemodialysis Patients

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