Receptor for Advanced Glycation End Products and Its Involvement in Inflammatory Diseases

The receptor for advanced glycation end products (RAGE) is a transmembrane receptor of the immunoglobulin superfamily, capable of binding a broad repertoire of ligands. RAGE-ligands interaction induces a series of signal transduction cascades and lead to the activation of transcription factor NF-κB...

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Main Authors:	Chuah, Yaw Kuang, Basir, Rusliza, Talib, Herni, Tie, Tung Hing, Nordin, Norshariza
Format:	Online
Language:	English
Published:	Hindawi Publishing Corporation 2013
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3786507/

id	pubmed-3786507
recordtype	oai_dc
spelling	pubmed-37865072013-10-07 Receptor for Advanced Glycation End Products and Its Involvement in Inflammatory Diseases Chuah, Yaw Kuang Basir, Rusliza Talib, Herni Tie, Tung Hing Nordin, Norshariza Review Article The receptor for advanced glycation end products (RAGE) is a transmembrane receptor of the immunoglobulin superfamily, capable of binding a broad repertoire of ligands. RAGE-ligands interaction induces a series of signal transduction cascades and lead to the activation of transcription factor NF-κB as well as increased expression of cytokines, chemokines, and adhesion molecules. These effects endow RAGE with the role in the signal transduction from pathogen substrates to cell activation during the onset and perpetuation of inflammation. RAGE signaling and downstream pathways have been implicated in a wide spectrum of inflammatory-related pathologic conditions such as arteriosclerosis, Alzheimer's disease, arthritis, acute respiratory failure, and sepsis. Despite the significant progress in other RAGE studies, the functional importance of the receptor in clinical situations and inflammatory diseases still remains to be fully realized. In this review, we will summarize current understandings and lines of evidence on the molecular mechanisms through which RAGE signaling contributes to the pathogenesis of the aforementioned inflammation-associated conditions. Hindawi Publishing Corporation 2013 2013-09-11 /pmc/articles/PMC3786507/ /pubmed/24102034 http://dx.doi.org/10.1155/2013/403460 Text en Copyright © 2013 Yaw Kuang Chuah et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Chuah, Yaw Kuang Basir, Rusliza Talib, Herni Tie, Tung Hing Nordin, Norshariza
spellingShingle	Chuah, Yaw Kuang Basir, Rusliza Talib, Herni Tie, Tung Hing Nordin, Norshariza Receptor for Advanced Glycation End Products and Its Involvement in Inflammatory Diseases
author_facet	Chuah, Yaw Kuang Basir, Rusliza Talib, Herni Tie, Tung Hing Nordin, Norshariza
author_sort	Chuah, Yaw Kuang
title	Receptor for Advanced Glycation End Products and Its Involvement in Inflammatory Diseases
title_short	Receptor for Advanced Glycation End Products and Its Involvement in Inflammatory Diseases
title_full	Receptor for Advanced Glycation End Products and Its Involvement in Inflammatory Diseases
title_fullStr	Receptor for Advanced Glycation End Products and Its Involvement in Inflammatory Diseases
title_full_unstemmed	Receptor for Advanced Glycation End Products and Its Involvement in Inflammatory Diseases
title_sort	receptor for advanced glycation end products and its involvement in inflammatory diseases
description	The receptor for advanced glycation end products (RAGE) is a transmembrane receptor of the immunoglobulin superfamily, capable of binding a broad repertoire of ligands. RAGE-ligands interaction induces a series of signal transduction cascades and lead to the activation of transcription factor NF-κB as well as increased expression of cytokines, chemokines, and adhesion molecules. These effects endow RAGE with the role in the signal transduction from pathogen substrates to cell activation during the onset and perpetuation of inflammation. RAGE signaling and downstream pathways have been implicated in a wide spectrum of inflammatory-related pathologic conditions such as arteriosclerosis, Alzheimer's disease, arthritis, acute respiratory failure, and sepsis. Despite the significant progress in other RAGE studies, the functional importance of the receptor in clinical situations and inflammatory diseases still remains to be fully realized. In this review, we will summarize current understandings and lines of evidence on the molecular mechanisms through which RAGE signaling contributes to the pathogenesis of the aforementioned inflammation-associated conditions.
publisher	Hindawi Publishing Corporation
publishDate	2013
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3786507/
_version_	1612015105371799552

Receptor for Advanced Glycation End Products and Its Involvement in Inflammatory Diseases

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