Occludin OCEL-domain interactions are required for maintenance and regulation of the tight junction barrier to macromolecular flux

Occludin OCEL-domain interactions are required for maintenance and regulation of the tight junction barrier to macromolecular flux

Occludin loss enhances paracellular macromolecular permeability (radius up to ∼62.5 Å) and is necessary for TNF-induced barrier loss. The latter requires the C-terminal OCEL domain, which stabilizes tight junction–associated occludin and regulates trafficking. Thus OCEL-mediated interactions are cri...

Full description

Bibliographic Details
Main Authors: Buschmann, Mary M., Shen, Le, Rajapakse, Harsha, Raleigh, David R., Wang, Yitang, Wang, Yingmin, Lingaraju, Amulya, Zha, Juanmin, Abbott, Elliot, McAuley, Erin M., Breskin, Lydia A., Wu, Licheng, Anderson, Kenneth, Turner, Jerrold R., Weber, Christopher R.
Format: Online
Language:English
Published: The American Society for Cell Biology 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3784380/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3784380/

Similar Items