Combined mutation of Vhl and Trp53 causes renal cysts and tumours in mice

Combined mutation of Vhl and Trp53 causes renal cysts and tumours in mice

The combinations of genetic alterations that cooperate with von Hippel–Lindau (VHL) mutation to cause clear cell renal cell carcinoma (ccRCC) remain poorly understood. We show that the TP53 tumour suppressor gene is mutated in approximately 9% of human ccRCCs. Combined deletion of Vhl and Trp53 in p...

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Bibliographic Details
Main Authors: Albers, Joachim, Rajski, Michal, Schönenberger, Désirée, Harlander, Sabine, Schraml, Peter, von Teichman, Adriana, Georgiev, Strahil, Wild, Peter J, Moch, Holger, Krek, Wilhelm, Frew, Ian J
Format: Online
Language:English
Published: WILEY-VCH Verlag 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3779454/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3779454/

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