Control of synaptic vesicle endocytosis by an extracellular signalling molecule

Signalling cascades control multiple aspects of presynaptic function. Synaptic vesicle endocytosis was assumed to be exempt from modulation, due to its essential role maintaining synaptic vesicle supply and thus neurotransmission. Here we show that brain-derived neurotrophic factor arrests the repho...

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Main Authors:	Smillie, Karen J., Pawson, Jonathan, Perkins, Emma M., Jackson, Mandy, Cousin, Michael A.
Format:	Online
Language:	English
Published:	Nature Pub. Group 2013
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3778765/

id	pubmed-3778765
recordtype	oai_dc
spelling	pubmed-37787652013-09-23 Control of synaptic vesicle endocytosis by an extracellular signalling molecule Smillie, Karen J. Pawson, Jonathan Perkins, Emma M. Jackson, Mandy Cousin, Michael A. Article Signalling cascades control multiple aspects of presynaptic function. Synaptic vesicle endocytosis was assumed to be exempt from modulation, due to its essential role maintaining synaptic vesicle supply and thus neurotransmission. Here we show that brain-derived neurotrophic factor arrests the rephosphorylation of the endocytosis enzyme dynamin I via an inhibition of glycogen synthase kinase 3. This event results in a selective inhibition of activity-dependent bulk endocytosis during high-intensity firing. Furthermore, the continued presence of brain-derived neurotrophic factor alleviates the rundown of neurotransmission during high activity. Thus, synaptic strength can be modulated by extracellular signalling molecules via a direct inhibition of a synaptic vesicle endocytosis mode. Nature Pub. Group 2013-09-03 /pmc/articles/PMC3778765/ /pubmed/23999152 http://dx.doi.org/10.1038/ncomms3394 Text en Copyright © 2013, Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved. http://creativecommons.org/licenses/by-nc-nd/3.0/ This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Smillie, Karen J. Pawson, Jonathan Perkins, Emma M. Jackson, Mandy Cousin, Michael A.
spellingShingle	Smillie, Karen J. Pawson, Jonathan Perkins, Emma M. Jackson, Mandy Cousin, Michael A. Control of synaptic vesicle endocytosis by an extracellular signalling molecule
author_facet	Smillie, Karen J. Pawson, Jonathan Perkins, Emma M. Jackson, Mandy Cousin, Michael A.
author_sort	Smillie, Karen J.
title	Control of synaptic vesicle endocytosis by an extracellular signalling molecule
title_short	Control of synaptic vesicle endocytosis by an extracellular signalling molecule
title_full	Control of synaptic vesicle endocytosis by an extracellular signalling molecule
title_fullStr	Control of synaptic vesicle endocytosis by an extracellular signalling molecule
title_full_unstemmed	Control of synaptic vesicle endocytosis by an extracellular signalling molecule
title_sort	control of synaptic vesicle endocytosis by an extracellular signalling molecule
description	Signalling cascades control multiple aspects of presynaptic function. Synaptic vesicle endocytosis was assumed to be exempt from modulation, due to its essential role maintaining synaptic vesicle supply and thus neurotransmission. Here we show that brain-derived neurotrophic factor arrests the rephosphorylation of the endocytosis enzyme dynamin I via an inhibition of glycogen synthase kinase 3. This event results in a selective inhibition of activity-dependent bulk endocytosis during high-intensity firing. Furthermore, the continued presence of brain-derived neurotrophic factor alleviates the rundown of neurotransmission during high activity. Thus, synaptic strength can be modulated by extracellular signalling molecules via a direct inhibition of a synaptic vesicle endocytosis mode.
publisher	Nature Pub. Group
publishDate	2013
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3778765/
_version_	1612013158868713472

Control of synaptic vesicle endocytosis by an extracellular signalling molecule

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