The influence of clan structure on the genetic variation in a single Ghanaian village

Socioeconomic and cultural factors are thought to have an important role in influencing human population genetic structure. To explain such population structure differences, most studies analyse genetic differences among widely dispersed human populations. In contrast, we have studied the genetic st...

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Main Authors:	Sanchez-Faddeev, Hernando, Pijpe, Jeroen, van der Hulle, Tom, Meij, Hans J, J van der Gaag, Kristiaan, Slagboom, P Eline, Westendorp, Rudi G J, de Knijff, Peter
Format:	Online
Language:	English
Published:	Nature Publishing Group 2013
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3778349/

id	pubmed-3778349
recordtype	oai_dc
spelling	pubmed-37783492013-10-01 The influence of clan structure on the genetic variation in a single Ghanaian village Sanchez-Faddeev, Hernando Pijpe, Jeroen van der Hulle, Tom Meij, Hans J J van der Gaag, Kristiaan Slagboom, P Eline Westendorp, Rudi G J de Knijff, Peter Article Socioeconomic and cultural factors are thought to have an important role in influencing human population genetic structure. To explain such population structure differences, most studies analyse genetic differences among widely dispersed human populations. In contrast, we have studied the genetic structure of an ethnic group occupying a single village in north-eastern Ghana. We found a markedly skewed male population substructure because of an almost complete lack of male gene flow among Bimoba clans in this village. We also observed a deep male substructure within one of the clans in this village. Among all males, we observed only three Y-single-nucleotide polymorphism (SNP) haplogroups: E1b1a-M2, E1b1a7a-U174 and E1b1a8a*-U209, P277, P278. In contrast to the marked Y-chromosomal substructure, mitochondrial DNA HVS-1 sequence variation and autosomal short-tandem repeats variation patterns indicate high genetic diversities and a virtually random female-mediated gene flow among clans. On the extreme micro-geographical scale of this single Bimoba village, correspondence between the Y-chromosome lineages and clan membership could be due to the combined effects of the strict patrilocal and patrilineal structure. If translated to larger geographic scales, our results would imply that the extent of variation in uniparentally inherited genetic markers, which are typically associated with historical migration on a continental scale, could equally likely be the result of many small and different cumulative effects of social factors such as clan membership that act at a local scale. Such local scale effects should therefore be considered in genetic studies, especially those that use uniparental markers, before making inferences about human history at large. Nature Publishing Group 2013-10 2013-02-27 /pmc/articles/PMC3778349/ /pubmed/23443025 http://dx.doi.org/10.1038/ejhg.2013.12 Text en Copyright © 2013 Macmillan Publishers Limited http://creativecommons.org/licenses/by-nc-nd/3.0/ This work is licensed under the Creative Commons Attribution-NonCommercial-No Derivative Works 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Sanchez-Faddeev, Hernando Pijpe, Jeroen van der Hulle, Tom Meij, Hans J J van der Gaag, Kristiaan Slagboom, P Eline Westendorp, Rudi G J de Knijff, Peter
spellingShingle	Sanchez-Faddeev, Hernando Pijpe, Jeroen van der Hulle, Tom Meij, Hans J J van der Gaag, Kristiaan Slagboom, P Eline Westendorp, Rudi G J de Knijff, Peter The influence of clan structure on the genetic variation in a single Ghanaian village
author_facet	Sanchez-Faddeev, Hernando Pijpe, Jeroen van der Hulle, Tom Meij, Hans J J van der Gaag, Kristiaan Slagboom, P Eline Westendorp, Rudi G J de Knijff, Peter
author_sort	Sanchez-Faddeev, Hernando
title	The influence of clan structure on the genetic variation in a single Ghanaian village
title_short	The influence of clan structure on the genetic variation in a single Ghanaian village
title_full	The influence of clan structure on the genetic variation in a single Ghanaian village
title_fullStr	The influence of clan structure on the genetic variation in a single Ghanaian village
title_full_unstemmed	The influence of clan structure on the genetic variation in a single Ghanaian village
title_sort	influence of clan structure on the genetic variation in a single ghanaian village
description	Socioeconomic and cultural factors are thought to have an important role in influencing human population genetic structure. To explain such population structure differences, most studies analyse genetic differences among widely dispersed human populations. In contrast, we have studied the genetic structure of an ethnic group occupying a single village in north-eastern Ghana. We found a markedly skewed male population substructure because of an almost complete lack of male gene flow among Bimoba clans in this village. We also observed a deep male substructure within one of the clans in this village. Among all males, we observed only three Y-single-nucleotide polymorphism (SNP) haplogroups: E1b1a-M2, E1b1a7a-U174 and E1b1a8a*-U209, P277, P278. In contrast to the marked Y-chromosomal substructure, mitochondrial DNA HVS-1 sequence variation and autosomal short-tandem repeats variation patterns indicate high genetic diversities and a virtually random female-mediated gene flow among clans. On the extreme micro-geographical scale of this single Bimoba village, correspondence between the Y-chromosome lineages and clan membership could be due to the combined effects of the strict patrilocal and patrilineal structure. If translated to larger geographic scales, our results would imply that the extent of variation in uniparentally inherited genetic markers, which are typically associated with historical migration on a continental scale, could equally likely be the result of many small and different cumulative effects of social factors such as clan membership that act at a local scale. Such local scale effects should therefore be considered in genetic studies, especially those that use uniparental markers, before making inferences about human history at large.
publisher	Nature Publishing Group
publishDate	2013
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3778349/
_version_	1612013039264989184

The influence of clan structure on the genetic variation in a single Ghanaian village

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