Southernmost Asia Is the Source of Japanese Encephalitis Virus (Genotype 1) Diversity from which the Viruses Disperse and Evolve throughout Asia

Southernmost Asia Is the Source of Japanese Encephalitis Virus (Genotype 1) Diversity from which the Viruses Disperse and Evolve throughout Asia

Japanese encephalitis virus (JEV) probably originated in the Malaysia/Indonesia region. Currently, there are no systematic studies that adequately define how it subsequently dispersed throughout Asia. In this study, we demonstrate that JEV lineages can be divided into four endemic cycles, comprising...

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Main Authors: Gao, Xiaoyan, Liu, Hong, Wang, Huanyu, Fu, Shihong, Guo, Zhenyang, Liang, Guodong
Format: Online
Language:English
Published: Public Library of Science 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3777887/
id pubmed-3777887
recordtype oai_dc
spelling pubmed-37778872013-09-25 Southernmost Asia Is the Source of Japanese Encephalitis Virus (Genotype 1) Diversity from which the Viruses Disperse and Evolve throughout Asia Gao, Xiaoyan Liu, Hong Wang, Huanyu Fu, Shihong Guo, Zhenyang Liang, Guodong Research Article Japanese encephalitis virus (JEV) probably originated in the Malaysia/Indonesia region. Currently, there are no systematic studies that adequately define how it subsequently dispersed throughout Asia. In this study, we demonstrate that JEV lineages can be divided into four endemic cycles, comprising southern Asia, eastern coastal Asia, western Asia, and central Asia. In each endemic cycle the source of virus was geographically independent regardless of year, vector, and host of isolation. The southernmost region (Thailand, Vietnam, and Yunnan Province, China) was identified as the most likely source of JEV transmission from its origin to the Asian continent. Based on the evidence, we identified three probable JEV dispersal routes from south to north. Analysis of JEV population dynamics further supports this view. Our results provide new insights into the understanding of JEV evolution and dispersal and highlight its potential for introduction into non-endemic areas. Public Library of Science 2013-09-19 /pmc/articles/PMC3777887/ /pubmed/24069502 http://dx.doi.org/10.1371/journal.pntd.0002459 Text en © 2013 Gao et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
repository_type Open Access Journal
institution_category Foreign Institution
institution US National Center for Biotechnology Information
building NCBI PubMed
collection Online Access
language English
format Online
author Gao, Xiaoyan
Liu, Hong
Wang, Huanyu
Fu, Shihong
Guo, Zhenyang
Liang, Guodong
spellingShingle Gao, Xiaoyan
Liu, Hong
Wang, Huanyu
Fu, Shihong
Guo, Zhenyang
Liang, Guodong
Southernmost Asia Is the Source of Japanese Encephalitis Virus (Genotype 1) Diversity from which the Viruses Disperse and Evolve throughout Asia
author_facet Gao, Xiaoyan
Liu, Hong
Wang, Huanyu
Fu, Shihong
Guo, Zhenyang
Liang, Guodong
author_sort Gao, Xiaoyan
title Southernmost Asia Is the Source of Japanese Encephalitis Virus (Genotype 1) Diversity from which the Viruses Disperse and Evolve throughout Asia
title_short Southernmost Asia Is the Source of Japanese Encephalitis Virus (Genotype 1) Diversity from which the Viruses Disperse and Evolve throughout Asia
title_full Southernmost Asia Is the Source of Japanese Encephalitis Virus (Genotype 1) Diversity from which the Viruses Disperse and Evolve throughout Asia
title_fullStr Southernmost Asia Is the Source of Japanese Encephalitis Virus (Genotype 1) Diversity from which the Viruses Disperse and Evolve throughout Asia
title_full_unstemmed Southernmost Asia Is the Source of Japanese Encephalitis Virus (Genotype 1) Diversity from which the Viruses Disperse and Evolve throughout Asia
title_sort southernmost asia is the source of japanese encephalitis virus (genotype 1) diversity from which the viruses disperse and evolve throughout asia
description Japanese encephalitis virus (JEV) probably originated in the Malaysia/Indonesia region. Currently, there are no systematic studies that adequately define how it subsequently dispersed throughout Asia. In this study, we demonstrate that JEV lineages can be divided into four endemic cycles, comprising southern Asia, eastern coastal Asia, western Asia, and central Asia. In each endemic cycle the source of virus was geographically independent regardless of year, vector, and host of isolation. The southernmost region (Thailand, Vietnam, and Yunnan Province, China) was identified as the most likely source of JEV transmission from its origin to the Asian continent. Based on the evidence, we identified three probable JEV dispersal routes from south to north. Analysis of JEV population dynamics further supports this view. Our results provide new insights into the understanding of JEV evolution and dispersal and highlight its potential for introduction into non-endemic areas.
publisher Public Library of Science
publishDate 2013
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3777887/
_version_ 1612012875260362752

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