The attenuation of retinal nerve fiber layer thickness and cognitive deterioration

Thinner retinal nerve fiber layer (RNFL) has been reported in Alzheimer’s disease (AD) patient. However, whether changes in RNFL thickness can predict the cognitive deterioration remains unknown. We therefore set out a prospective clinical investigation to determine the potential association between...

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Main Authors:	Shen, Yuan, Shi, Zhongyong, Jia, Renbao, Zhu, Yikang, Cheng, Yan, Feng, Wei, Li, Chunbo
Format:	Online
Language:	English
Published:	Frontiers Media S.A. 2013
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3777215/

id	pubmed-3777215
recordtype	oai_dc
spelling	pubmed-37772152013-09-24 The attenuation of retinal nerve fiber layer thickness and cognitive deterioration Shen, Yuan Shi, Zhongyong Jia, Renbao Zhu, Yikang Cheng, Yan Feng, Wei Li, Chunbo Neuroscience Thinner retinal nerve fiber layer (RNFL) has been reported in Alzheimer’s disease (AD) patient. However, whether changes in RNFL thickness can predict the cognitive deterioration remains unknown. We therefore set out a prospective clinical investigation to determine the potential association between the attenuation of RNFL thickness and the deterioration of cognitive function over a period of 25 months. We assessed cognitive function using the Repeatable Battery for the Assessment of Neuropsychological Status and measured RNFL thickness employing optical coherence tomography in 78 participants (mean age 72.31 ± 3.98 years, 52% men). The participants were categorized as stable participants whose cognitive status remained no change (N = 60) and converted participants whose cognitive status deteriorated (N = 18). We found that there was an association between the attenuation of superior quadrant RNFL thickness and the deterioration of cognitive function in the stable participants. In the converted participants, however, there was an inverse association between the reduction of inferior quadrant RNFL thickness and decline of cognitive functions [scores of list recall (R = -0.670, P = 0.002), adjusted (R = -0.493, P = 0.031)]. These data showed that less reduction in the inferior quadrant of RNFL thickness might indicate a higher risk for the patients to develop cognitive deterioration. These findings have established a system to embark a larger scale study to further test whether changes in RNFL thickness can serve as a biomarker of AD, and would lead to mechanistic studies to determine the cellular mechanisms of cognitive deterioration. Frontiers Media S.A. 2013-09-19 /pmc/articles/PMC3777215/ /pubmed/24065883 http://dx.doi.org/10.3389/fncel.2013.00142 Text en Copyright © Shen, Shi, Jia, Zhu, Cheng, Feng and Li. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Shen, Yuan Shi, Zhongyong Jia, Renbao Zhu, Yikang Cheng, Yan Feng, Wei Li, Chunbo
spellingShingle	Shen, Yuan Shi, Zhongyong Jia, Renbao Zhu, Yikang Cheng, Yan Feng, Wei Li, Chunbo The attenuation of retinal nerve fiber layer thickness and cognitive deterioration
author_facet	Shen, Yuan Shi, Zhongyong Jia, Renbao Zhu, Yikang Cheng, Yan Feng, Wei Li, Chunbo
author_sort	Shen, Yuan
title	The attenuation of retinal nerve fiber layer thickness and cognitive deterioration
title_short	The attenuation of retinal nerve fiber layer thickness and cognitive deterioration
title_full	The attenuation of retinal nerve fiber layer thickness and cognitive deterioration
title_fullStr	The attenuation of retinal nerve fiber layer thickness and cognitive deterioration
title_full_unstemmed	The attenuation of retinal nerve fiber layer thickness and cognitive deterioration
title_sort	attenuation of retinal nerve fiber layer thickness and cognitive deterioration
description	Thinner retinal nerve fiber layer (RNFL) has been reported in Alzheimer’s disease (AD) patient. However, whether changes in RNFL thickness can predict the cognitive deterioration remains unknown. We therefore set out a prospective clinical investigation to determine the potential association between the attenuation of RNFL thickness and the deterioration of cognitive function over a period of 25 months. We assessed cognitive function using the Repeatable Battery for the Assessment of Neuropsychological Status and measured RNFL thickness employing optical coherence tomography in 78 participants (mean age 72.31 ± 3.98 years, 52% men). The participants were categorized as stable participants whose cognitive status remained no change (N = 60) and converted participants whose cognitive status deteriorated (N = 18). We found that there was an association between the attenuation of superior quadrant RNFL thickness and the deterioration of cognitive function in the stable participants. In the converted participants, however, there was an inverse association between the reduction of inferior quadrant RNFL thickness and decline of cognitive functions [scores of list recall (R = -0.670, P = 0.002), adjusted (R = -0.493, P = 0.031)]. These data showed that less reduction in the inferior quadrant of RNFL thickness might indicate a higher risk for the patients to develop cognitive deterioration. These findings have established a system to embark a larger scale study to further test whether changes in RNFL thickness can serve as a biomarker of AD, and would lead to mechanistic studies to determine the cellular mechanisms of cognitive deterioration.
publisher	Frontiers Media S.A.
publishDate	2013
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3777215/
_version_	1612012707161047040

The attenuation of retinal nerve fiber layer thickness and cognitive deterioration

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