Preclinical Development of a Novel Class of CXCR4 Antagonist Impairing Solid Tumors Growth and Metastases

Preclinical Development of a Novel Class of CXCR4 Antagonist Impairing Solid Tumors Growth and Metastases

The CXCR4/CXCL12 axis plays a role in cancer metastases, stem cell mobilization and chemosensitization. Proof of concept for efficient CXCR4 inhibition has been demonstrated in stem cell mobilization prior to autologous transplantation in hematological malignancies. Nevertheless CXCR4 inhibitors sui...

Full description

Bibliographic Details
Main Authors: Portella, Luigi, Vitale, Rosamaria, De Luca, Stefania, D’Alterio, Crescenzo, Ieranò, Caterina, Napolitano, Maria, Riccio, Anna, Polimeno, Maria Neve, Monfregola, Luca, Barbieri, Antonio, Luciano, Antonio, Ciarmiello, Andrea, Arra, Claudio, Castello, Giuseppe, Amodeo, Pietro, Scala, Stefania
Format: Online
Language:English
Published: Public Library of Science 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3772838/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3772838/

Similar Items