JAK-STAT and bone metabolism
Emerging evidences suggest Janus kinase (JAK)-signal transducer and activator of transcription (STAT) signaling pathway plays an important role in bone development and metabolism. Effects of JAK-STAT pathway on skeletal development are summarized based on skeletal phenotype of individual JAK and STA...
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| Format: | Online |
| Language: | English |
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Landes Bioscience
2013
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3772100/ |
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pubmed-3772100 |
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pubmed-37721002013-09-25 JAK-STAT and bone metabolism Li, Jiliang Review Emerging evidences suggest Janus kinase (JAK)-signal transducer and activator of transcription (STAT) signaling pathway plays an important role in bone development and metabolism. Effects of JAK-STAT pathway on skeletal development are summarized based on skeletal phenotype of individual JAK and STAT gene knockout mouse. Furthermore, STAT3 has more profound effects on bone homeostasis compared with the other STATs. STAT3 mutation causes a disease called Job syndrome, most patients with which have associated craniofacial and skeletal features. Selective inactivation of STAT3 in osteoblasts decreases bone formation and skeletal responsiveness to mechanical loading. Future research includes investigating JAK-STAT signaling in osteoclasts and osteocytes. Landes Bioscience 2013-07-01 2013-08-15 /pmc/articles/PMC3772100/ /pubmed/24069548 http://dx.doi.org/10.4161/jkst.23930 Text en Copyright © 2013 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited. |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Li, Jiliang |
| spellingShingle |
Li, Jiliang JAK-STAT and bone metabolism |
| author_facet |
Li, Jiliang |
| author_sort |
Li, Jiliang |
| title |
JAK-STAT and bone metabolism |
| title_short |
JAK-STAT and bone metabolism |
| title_full |
JAK-STAT and bone metabolism |
| title_fullStr |
JAK-STAT and bone metabolism |
| title_full_unstemmed |
JAK-STAT and bone metabolism |
| title_sort |
jak-stat and bone metabolism |
| description |
Emerging evidences suggest Janus kinase (JAK)-signal transducer and activator of transcription (STAT) signaling pathway plays an important role in bone development and metabolism. Effects of JAK-STAT pathway on skeletal development are summarized based on skeletal phenotype of individual JAK and STAT gene knockout mouse. Furthermore, STAT3 has more profound effects on bone homeostasis compared with the other STATs. STAT3 mutation causes a disease called Job syndrome, most patients with which have associated craniofacial and skeletal features. Selective inactivation of STAT3 in osteoblasts decreases bone formation and skeletal responsiveness to mechanical loading. Future research includes investigating JAK-STAT signaling in osteoclasts and osteocytes. |
| publisher |
Landes Bioscience |
| publishDate |
2013 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3772100/ |
| _version_ |
1612011386746961920 |