Relationship between total homocysteine, total cholesterol and creatinine levels in overt hypothyroid patients

Hypothyroidism is associated with an increased risk for cardiovascular disease, which can not be fully explained by the atherogenic lipid profile, particularly total cholesterol and LDL-C, and other pathogenic factors may be involved. Plasma total homocysteine (tHcy) is an independent risk factor fo...

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Main Authors:	Bamashmoos, Saleh A, Al-Nuzaily, Mohammed AK, Al-Meeri, Ali M, Ali, Faisal HH
Format:	Online
Language:	English
Published:	Springer International Publishing 2013
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3766507/

id	pubmed-3766507
recordtype	oai_dc
spelling	pubmed-37665072013-09-10 Relationship between total homocysteine, total cholesterol and creatinine levels in overt hypothyroid patients Bamashmoos, Saleh A Al-Nuzaily, Mohammed AK Al-Meeri, Ali M Ali, Faisal HH Research Hypothyroidism is associated with an increased risk for cardiovascular disease, which can not be fully explained by the atherogenic lipid profile, particularly total cholesterol and LDL-C, and other pathogenic factors may be involved. Plasma total homocysteine (tHcy) is an independent risk factor for cardiovascular disease and accelerated atherosclerosis. The aim of this study was to investigate the serum total homocysteine (tHcy) levels and its relation to total cholesterol, creatinine and thyroid hormones fT3, fT4 and TSH levels in overt hypothyroid patients compared to control subjects. In this study thirty recently diagnosed, non-treated overt hypothyroid patients (f=27, m=3) and twenty normal volunteers control (f=18, m=2) were included and subjected to determination of serum tHcy by enzyme immunoassay (EIA) technique, fT3, fT4 and TSH by Elecsys cobas e 601 analyzer, total cholesterol by enzymatic method and creatinine by kinetic method. The data was statistically analysed by SPSS-10 and p values less than 0.05 were considered significant.Our results showed that there were a significant increase of tHcy, TSH, T.cholesterol and creatinine levels by 113%, 12-folds, 58% and 54%, respectively, and a significant decrease of fT4 and fT3 levels by 49.6% and 56.4% , respectively, in hypothyroid patients than in control group. For tHcy (Mean±SD, 24.45±5.50 μmol/l vs 11.48±3.03 μmol/l, respectively; P < 0.001). tHcy was significantly positively correlated with TSH, creatinine and age and negatively correlated with free thyroxine (fT4) and no significant correlations with fT3 and T.cholesterol. In conclusion, our study confirmed the observation of elevated serum tHcy, T.cholesterol and creatinine in overt hypothyroidism and the presence of an inverse relation between tHcy with fT4 and a positive relation with TSH. Springer International Publishing 2013-08-30 /pmc/articles/PMC3766507/ /pubmed/24024107 http://dx.doi.org/10.1186/2193-1801-2-423 Text en © Bamashmoos et al.; licensee Springer. 2013 This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Bamashmoos, Saleh A Al-Nuzaily, Mohammed AK Al-Meeri, Ali M Ali, Faisal HH
spellingShingle	Bamashmoos, Saleh A Al-Nuzaily, Mohammed AK Al-Meeri, Ali M Ali, Faisal HH Relationship between total homocysteine, total cholesterol and creatinine levels in overt hypothyroid patients
author_facet	Bamashmoos, Saleh A Al-Nuzaily, Mohammed AK Al-Meeri, Ali M Ali, Faisal HH
author_sort	Bamashmoos, Saleh A
title	Relationship between total homocysteine, total cholesterol and creatinine levels in overt hypothyroid patients
title_short	Relationship between total homocysteine, total cholesterol and creatinine levels in overt hypothyroid patients
title_full	Relationship between total homocysteine, total cholesterol and creatinine levels in overt hypothyroid patients
title_fullStr	Relationship between total homocysteine, total cholesterol and creatinine levels in overt hypothyroid patients
title_full_unstemmed	Relationship between total homocysteine, total cholesterol and creatinine levels in overt hypothyroid patients
title_sort	relationship between total homocysteine, total cholesterol and creatinine levels in overt hypothyroid patients
description	Hypothyroidism is associated with an increased risk for cardiovascular disease, which can not be fully explained by the atherogenic lipid profile, particularly total cholesterol and LDL-C, and other pathogenic factors may be involved. Plasma total homocysteine (tHcy) is an independent risk factor for cardiovascular disease and accelerated atherosclerosis. The aim of this study was to investigate the serum total homocysteine (tHcy) levels and its relation to total cholesterol, creatinine and thyroid hormones fT3, fT4 and TSH levels in overt hypothyroid patients compared to control subjects. In this study thirty recently diagnosed, non-treated overt hypothyroid patients (f=27, m=3) and twenty normal volunteers control (f=18, m=2) were included and subjected to determination of serum tHcy by enzyme immunoassay (EIA) technique, fT3, fT4 and TSH by Elecsys cobas e 601 analyzer, total cholesterol by enzymatic method and creatinine by kinetic method. The data was statistically analysed by SPSS-10 and p values less than 0.05 were considered significant.Our results showed that there were a significant increase of tHcy, TSH, T.cholesterol and creatinine levels by 113%, 12-folds, 58% and 54%, respectively, and a significant decrease of fT4 and fT3 levels by 49.6% and 56.4% , respectively, in hypothyroid patients than in control group. For tHcy (Mean±SD, 24.45±5.50 μmol/l vs 11.48±3.03 μmol/l, respectively; P < 0.001). tHcy was significantly positively correlated with TSH, creatinine and age and negatively correlated with free thyroxine (fT4) and no significant correlations with fT3 and T.cholesterol. In conclusion, our study confirmed the observation of elevated serum tHcy, T.cholesterol and creatinine in overt hypothyroidism and the presence of an inverse relation between tHcy with fT4 and a positive relation with TSH.
publisher	Springer International Publishing
publishDate	2013
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3766507/
_version_	1612009633879162880

Relationship between total homocysteine, total cholesterol and creatinine levels in overt hypothyroid patients

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