Changes in Ect2 Localization Couple Actomyosin-Dependent Cell Shape Changes to Mitotic Progression
As they enter mitosis, animal cells undergo profound actin-dependent changes in shape to become round. Here we identify the Cdk1 substrate, Ect2, as a central regulator of mitotic rounding, thus uncovering a link between the cell-cycle machinery that drives mitotic entry and its accompanying actin r...
| Main Authors: | , , , , , |
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| Format: | Online |
| Language: | English |
| Published: |
Cell Press
2012
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3763371/ |