The HDAC Inhibitor LBH589 Induces ERK-Dependent Prometaphase Arrest in Prostate Cancer via HDAC6 Inactivation and Down-Regulation

The HDAC Inhibitor LBH589 Induces ERK-Dependent Prometaphase Arrest in Prostate Cancer via HDAC6 Inactivation and Down-Regulation

Histone deacetylase inhibitors (HDACIs) have potent anti-cancer activity in a variety of cancer models. Understanding the molecular mechanisms involved in the therapeutic responsiveness of HDACI is needed before its clinical application. This study aimed to determine if a potent HDACI, LBH589 (Panob...

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Bibliographic Details
Main Authors: Chuang, Mei-Jen, Wu, Sheng-Tang, Tang, Shou-Hung, Lai, Xiang-Me, Lai, Hsiao-Chu, Hsu, Kai-Hsiang, Sun, Kuang-Hui, Sun, Guang-Huan, Chang, Sun-Yran, Yu, Dah-Shyong, Hsiao, Pei-Wen, Huang, Shih-Ming, Cha, Tai-Lung
Format: Online
Language:English
Published: Public Library of Science 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3762759/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3762759/

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