An Altered gp100 Peptide Ligand with Decreased Binding by TCR and CD8α Dissects T Cell Cytotoxicity from Production of Cytokines and Activation of NFAT

An Altered gp100 Peptide Ligand with Decreased Binding by TCR and CD8α Dissects T Cell Cytotoxicity from Production of Cytokines and Activation of NFAT

Altered peptide ligands (APLs) provide useful tools to study T cell activation and potentially direct immune responses to improve treatment of cancer patients. To better understand and exploit APLs, we studied the relationship between APLs and T cell function in more detail. Here, we tested a broad...

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Bibliographic Details
Main Authors: Schaft, Niels, Coccoris, Miriam, Drexhage, Joost, Knoop, Christiaan, de Vries, I. Jolanda M., Adema, Gosse J., Debets, Reno
Format: Online
Language:English
Published: Frontiers Media S.A. 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3762364/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3762364/

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