Host Restriction of Lentiviruses and Viral Countermeasures: APOBEC3 and Vif
It is becoming increasingly clear that organisms have developed a variety of mechanisms to fight against viral infection. The viruses have developed means of counteracting these defences in various ways. The APOBEC3 proteins are a mammalian-specific family of nucleic acid cytidine deaminases that bl...
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| Format: | Online |
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MDPI
2013
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3761234/ |
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pubmed-37612342013-09-04 Host Restriction of Lentiviruses and Viral Countermeasures: APOBEC3 and Vif Jónsson, Stefán R. Andrésdóttir, Valgerdur Review It is becoming increasingly clear that organisms have developed a variety of mechanisms to fight against viral infection. The viruses have developed means of counteracting these defences in various ways. The APOBEC3 proteins are a mammalian-specific family of nucleic acid cytidine deaminases that block retroviral infection. These inhibitors are counteracted by the Vif proteins encoded by most lentiviruses. In this paper, we will review the interaction of the lentiviral Vif proteins with the APOBEC3 proteins, with an emphasis on sheep APOBEC3 and maedi-visna virus (MVV) Vif. MDPI 2013-07-30 /pmc/articles/PMC3761234/ /pubmed/23903287 http://dx.doi.org/10.3390/v5081934 Text en © 2013 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Jónsson, Stefán R. Andrésdóttir, Valgerdur |
| spellingShingle |
Jónsson, Stefán R. Andrésdóttir, Valgerdur Host Restriction of Lentiviruses and Viral Countermeasures: APOBEC3 and Vif |
| author_facet |
Jónsson, Stefán R. Andrésdóttir, Valgerdur |
| author_sort |
Jónsson, Stefán R. |
| title |
Host Restriction of Lentiviruses and Viral Countermeasures: APOBEC3 and Vif |
| title_short |
Host Restriction of Lentiviruses and Viral Countermeasures: APOBEC3 and Vif |
| title_full |
Host Restriction of Lentiviruses and Viral Countermeasures: APOBEC3 and Vif |
| title_fullStr |
Host Restriction of Lentiviruses and Viral Countermeasures: APOBEC3 and Vif |
| title_full_unstemmed |
Host Restriction of Lentiviruses and Viral Countermeasures: APOBEC3 and Vif |
| title_sort |
host restriction of lentiviruses and viral countermeasures: apobec3 and vif |
| description |
It is becoming increasingly clear that organisms have developed a variety of mechanisms to fight against viral infection. The viruses have developed means of counteracting these defences in various ways. The APOBEC3 proteins are a mammalian-specific family of nucleic acid cytidine deaminases that block retroviral infection. These inhibitors are counteracted by the Vif proteins encoded by most lentiviruses. In this paper, we will review the interaction of the lentiviral Vif proteins with the APOBEC3 proteins, with an emphasis on sheep APOBEC3 and maedi-visna virus (MVV) Vif. |
| publisher |
MDPI |
| publishDate |
2013 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3761234/ |
| _version_ |
1612008059257749504 |