Review: dermatitis herpetiformis*

Review: dermatitis herpetiformis*

Dermatitis herpetiformis (DH) or Duhring-Brocq disease is a chronic bullous disease characterized by intense itching and burning sensation in the erythematous papules and urticarial plaques, grouped vesicles with centrifuge growth, and tense blisters. There is an association with the genotypes HLA D...

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Main Authors: Mendes, Fernanda Berti Rocha, Hissa-Elian, Adaucto, de Abreu, Marilda Aparecida Milanez Morgado, Gonçalves, Virgínica Scaff
Format: Online
Language:English
Published: Sociedade Brasileira de Dermatologia 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3760935/
id pubmed-3760935
recordtype oai_dc
spelling pubmed-37609352013-09-16 Review: dermatitis herpetiformis* Mendes, Fernanda Berti Rocha Hissa-Elian, Adaucto de Abreu, Marilda Aparecida Milanez Morgado Gonçalves, Virgínica Scaff Review Dermatitis herpetiformis (DH) or Duhring-Brocq disease is a chronic bullous disease characterized by intense itching and burning sensation in the erythematous papules and urticarial plaques, grouped vesicles with centrifuge growth, and tense blisters. There is an association with the genotypes HLA DR3, HLA DQw2, found in 80-90% of cases. It is an IgA-mediated cutaneous disease, with immunoglobulin A deposits appearing in a granular pattern at the top of the dermal papilla in the sublamina densa area of the basement membrane, which is present both in affected skin and healthy skin. The same protein IgA1 with J chain is found in the small intestinal mucosa in patients with adult celiac disease, suggesting a strong association with DH. Specific antibodies such as antiendomysium, antireticulina, antigliadin and, recently identified, the epidermal and tissue transglutaminase subtypes, as well as increased zonulin production, are common to both conditions, along with gluten-sensitive enteropathy and DH. Autoimmune diseases present higher levels of prevalence, such as thyroid (5-11%), pernicious anemia (1-3%), type 1 diabetes (1-2%) and collagen tissue disease. The chosen treatment is dapsone and a gluten-free diet. Sociedade Brasileira de Dermatologia 2013 /pmc/articles/PMC3760935/ /pubmed/24068131 http://dx.doi.org/10.1590/abd1806-4841.20131775 Text en ©2013 by Anais Brasileiros de Dermatologia http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
repository_type Open Access Journal
institution_category Foreign Institution
institution US National Center for Biotechnology Information
building NCBI PubMed
collection Online Access
language English
format Online
author Mendes, Fernanda Berti Rocha
Hissa-Elian, Adaucto
de Abreu, Marilda Aparecida Milanez Morgado
Gonçalves, Virgínica Scaff
spellingShingle Mendes, Fernanda Berti Rocha
Hissa-Elian, Adaucto
de Abreu, Marilda Aparecida Milanez Morgado
Gonçalves, Virgínica Scaff
Review: dermatitis herpetiformis*
author_facet Mendes, Fernanda Berti Rocha
Hissa-Elian, Adaucto
de Abreu, Marilda Aparecida Milanez Morgado
Gonçalves, Virgínica Scaff
author_sort Mendes, Fernanda Berti Rocha
title Review: dermatitis herpetiformis*
title_short Review: dermatitis herpetiformis*
title_full Review: dermatitis herpetiformis*
title_fullStr Review: dermatitis herpetiformis*
title_full_unstemmed Review: dermatitis herpetiformis*
title_sort review: dermatitis herpetiformis*
description Dermatitis herpetiformis (DH) or Duhring-Brocq disease is a chronic bullous disease characterized by intense itching and burning sensation in the erythematous papules and urticarial plaques, grouped vesicles with centrifuge growth, and tense blisters. There is an association with the genotypes HLA DR3, HLA DQw2, found in 80-90% of cases. It is an IgA-mediated cutaneous disease, with immunoglobulin A deposits appearing in a granular pattern at the top of the dermal papilla in the sublamina densa area of the basement membrane, which is present both in affected skin and healthy skin. The same protein IgA1 with J chain is found in the small intestinal mucosa in patients with adult celiac disease, suggesting a strong association with DH. Specific antibodies such as antiendomysium, antireticulina, antigliadin and, recently identified, the epidermal and tissue transglutaminase subtypes, as well as increased zonulin production, are common to both conditions, along with gluten-sensitive enteropathy and DH. Autoimmune diseases present higher levels of prevalence, such as thyroid (5-11%), pernicious anemia (1-3%), type 1 diabetes (1-2%) and collagen tissue disease. The chosen treatment is dapsone and a gluten-free diet.
publisher Sociedade Brasileira de Dermatologia
publishDate 2013
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3760935/
_version_ 1612008010614308864

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