Expression of SIRT1 and DBC1 Is Associated with Poor Prognosis of Soft Tissue Sarcomas
Recently, the roles of SIRT1 and deleted in breast cancer 1 (DBC1) in human cancer have been extensively studied and it has been demonstrated that they are involved in many human carcinomas. However, their clinical significance for soft-tissue sarcomas has not been examined. In this study, we evalua...
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| Format: | Online |
| Language: | English |
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Public Library of Science
2013
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3760851/ |
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pubmed-37608512013-09-09 Expression of SIRT1 and DBC1 Is Associated with Poor Prognosis of Soft Tissue Sarcomas Kim, Jung Ryul Moon, Young Jae Kwon, Keun Sang Bae, Jun Sang Wagle, Sajeev Yu, Taek Kyun Kim, Kyoung Min Park, Ho Sung Lee, Ju-Hyung Moon, Woo Sung Lee, Ho Chung, Myoung Ja Jang, Kyu Yun Research Article Recently, the roles of SIRT1 and deleted in breast cancer 1 (DBC1) in human cancer have been extensively studied and it has been demonstrated that they are involved in many human carcinomas. However, their clinical significance for soft-tissue sarcomas has not been examined. In this study, we evaluated the expression and prognostic significance of the expression of SIRT1, DBC1, P53, β-catenin, cyclin D1, and KI67 in 104 cases of soft-tissue sarcomas. RESULTS: Immunohistochemical expression of SIRT1, DBC1, P53, β-catenin, and cyclin D1 were seen in 71%, 74%, 53%, 48%, and 73% of sarcomas, respectively. The expression of SIRT1, DBC1, P53, β-catenin, and cyclin D1 were significantly correlated with advanced clinicopathological parameters such as higher clinical stage, higher histological grade, increased mitotic counts, and distant metastasis. The expression of SIRT1, DBC1, P53, β-catenin, cyclin D1, and KI67 were significantly correlated with each other and positive expression of all of these predicted shorter overall survival and event-free survival by univariate analysis. Multivariate analysis revealed the expression of SIRT1 as an independent prognostic indicator for overall survival and event-free survival of sarcoma patients. In conclusion, this study demonstrates that SIRT1- and DBC1-related pathways may be involved in the progression of soft-tissue sarcomas and can be used as clinically significant prognostic indicators for sarcoma patients. Moreover, the SIRT1- and DBC1-related pathways could be new therapeutic targets for the treatment of sarcomas. Public Library of Science 2013-09-03 /pmc/articles/PMC3760851/ /pubmed/24019980 http://dx.doi.org/10.1371/journal.pone.0074738 Text en © 2013 Kim et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Kim, Jung Ryul Moon, Young Jae Kwon, Keun Sang Bae, Jun Sang Wagle, Sajeev Yu, Taek Kyun Kim, Kyoung Min Park, Ho Sung Lee, Ju-Hyung Moon, Woo Sung Lee, Ho Chung, Myoung Ja Jang, Kyu Yun |
| spellingShingle |
Kim, Jung Ryul Moon, Young Jae Kwon, Keun Sang Bae, Jun Sang Wagle, Sajeev Yu, Taek Kyun Kim, Kyoung Min Park, Ho Sung Lee, Ju-Hyung Moon, Woo Sung Lee, Ho Chung, Myoung Ja Jang, Kyu Yun Expression of SIRT1 and DBC1 Is Associated with Poor Prognosis of Soft Tissue Sarcomas |
| author_facet |
Kim, Jung Ryul Moon, Young Jae Kwon, Keun Sang Bae, Jun Sang Wagle, Sajeev Yu, Taek Kyun Kim, Kyoung Min Park, Ho Sung Lee, Ju-Hyung Moon, Woo Sung Lee, Ho Chung, Myoung Ja Jang, Kyu Yun |
| author_sort |
Kim, Jung Ryul |
| title |
Expression of SIRT1 and DBC1 Is Associated with Poor Prognosis of Soft Tissue Sarcomas |
| title_short |
Expression of SIRT1 and DBC1 Is Associated with Poor Prognosis of Soft Tissue Sarcomas |
| title_full |
Expression of SIRT1 and DBC1 Is Associated with Poor Prognosis of Soft Tissue Sarcomas |
| title_fullStr |
Expression of SIRT1 and DBC1 Is Associated with Poor Prognosis of Soft Tissue Sarcomas |
| title_full_unstemmed |
Expression of SIRT1 and DBC1 Is Associated with Poor Prognosis of Soft Tissue Sarcomas |
| title_sort |
expression of sirt1 and dbc1 is associated with poor prognosis of soft tissue sarcomas |
| description |
Recently, the roles of SIRT1 and deleted in breast cancer 1 (DBC1) in human cancer have been extensively studied and it has been demonstrated that they are involved in many human carcinomas. However, their clinical significance for soft-tissue sarcomas has not been examined. In this study, we evaluated the expression and prognostic significance of the expression of SIRT1, DBC1, P53, β-catenin, cyclin D1, and KI67 in 104 cases of soft-tissue sarcomas. RESULTS: Immunohistochemical expression of SIRT1, DBC1, P53, β-catenin, and cyclin D1 were seen in 71%, 74%, 53%, 48%, and 73% of sarcomas, respectively. The expression of SIRT1, DBC1, P53, β-catenin, and cyclin D1 were significantly correlated with advanced clinicopathological parameters such as higher clinical stage, higher histological grade, increased mitotic counts, and distant metastasis. The expression of SIRT1, DBC1, P53, β-catenin, cyclin D1, and KI67 were significantly correlated with each other and positive expression of all of these predicted shorter overall survival and event-free survival by univariate analysis. Multivariate analysis revealed the expression of SIRT1 as an independent prognostic indicator for overall survival and event-free survival of sarcoma patients. In conclusion, this study demonstrates that SIRT1- and DBC1-related pathways may be involved in the progression of soft-tissue sarcomas and can be used as clinically significant prognostic indicators for sarcoma patients. Moreover, the SIRT1- and DBC1-related pathways could be new therapeutic targets for the treatment of sarcomas. |
| publisher |
Public Library of Science |
| publishDate |
2013 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3760851/ |
| _version_ |
1612007963969454080 |