FGF-23 Regulates CYP27B1 Transcription in the Kidney and in Extra-Renal Tissues

FGF-23 Regulates CYP27B1 Transcription in the Kidney and in Extra-Renal Tissues

The mitochondrial enzyme 25-hydroxyvitamin D 1α-hydroxylase, which is encoded by the CYP27B1 gene, converts 25OHD to the biological active form of vitamin D, 1,25-dihydroxyvitamin D (1,25(OH)2D). Renal 1α-hydroxylase activity is the principal determinant of the circulating 1,25(OH)2D concentration a...

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Bibliographic Details
Main Authors: Chanakul, Ankanee, Zhang, Martin Y. H., Louw, Andrew, Armbrecht, Harvey J., Miller, Walter L., Portale, Anthony A., Perwad, Farzana
Format: Online
Language:English
Published: Public Library of Science 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3760837/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3760837/

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