Common folate gene variant, MTHFR C677T, is associated with brain structure in two independent cohorts of people with mild cognitive impairment☆

Common folate gene variant, MTHFR C677T, is associated with brain structure in two independent cohorts of people with mild cognitive impairment☆

A commonly carried C677T polymorphism in a folate-related gene, MTHFR, is associated with higher plasma homocysteine, a well-known mediator of neuronal damage and brain atrophy.

Bibliographic Details
Main Authors: Rajagopalan, Priya, Jahanshad, Neda, Stein, Jason L., Hua, Xue, Madsen, Sarah K., Kohannim, Omid, Hibar, Derrek P., Toga, Arthur W., Jack, Clifford R., Saykin, Andrew J., Green, Robert C., Weiner, Michael W., Bis, Joshua C., Kuller, Lewis H., Riverol, Mario, Becker, James T., Lopez, Oscar L., Thompson, Paul M.
Format: Online
Language:English
Published: Elsevier 2012
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3757723/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3757723/

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