Use of a Small Peptide Fragment as an Inhibitor of Insulin Fibrillation Process: A Study by High and Low Resolution Spectroscopy

Use of a Small Peptide Fragment as an Inhibitor of Insulin Fibrillation Process: A Study by High and Low Resolution Spectroscopy

A non-toxic, nine residue peptide, NIVNVSLVK is shown to interfere with insulin fibrillation by various biophysical methods. Insulin undergoes conformational changes under certain stress conditions leading to amyloid fibrils. Fibrillation of insulin poses a problem in its long-term storage, reducing...

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Bibliographic Details
Main Authors: Banerjee, Victor, Kar, Rajiv K., Datta, Aritreyee, Parthasarathi, Krupakar, Chatterjee, Subhrangsu, Das, Kali P., Bhunia, Anirban
Format: Online
Language:English
Published: Public Library of Science 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3756998/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3756998/

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