p53 SUMOylation promotes its nuclear export by facilitating its release from the nuclear export receptor CRM1

p53 SUMOylation promotes its nuclear export. The SIM-binding groove of a SUMO moiety linked to p53 and a SIM in CRM1 regulates their interaction. CRM1 binds to tetrameric p53 with a properly folded core domain, and CRM1 with a mutated SIM in the HEAT9 loop accumulates with SUMOylated p53 at NPCs and...

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Main Authors:	Santiago, Aleixo, Li, Dawei, Zhao, Lisa Y., Godsey, Adam, Liao, Daiqing
Format:	Online
Language:	English
Published:	The American Society for Cell Biology 2013
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3756925/

id	pubmed-3756925
recordtype	oai_dc
spelling	pubmed-37569252013-11-16 p53 SUMOylation promotes its nuclear export by facilitating its release from the nuclear export receptor CRM1 Santiago, Aleixo Li, Dawei Zhao, Lisa Y. Godsey, Adam Liao, Daiqing Articles p53 SUMOylation promotes its nuclear export. The SIM-binding groove of a SUMO moiety linked to p53 and a SIM in CRM1 regulates their interaction. CRM1 binds to tetrameric p53 with a properly folded core domain, and CRM1 with a mutated SIM in the HEAT9 loop accumulates with SUMOylated p53 at NPCs and cytoplasmic aggregates. The American Society for Cell Biology 2013-09-01 /pmc/articles/PMC3756925/ /pubmed/23825024 http://dx.doi.org/10.1091/mbc.E12-10-0771 Text en © 2013 Santiago et al. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0). “ASCB®,” “The American Society for Cell Biology®,” and “Molecular Biology of the Cell®” are registered trademarks of The American Society of Cell Biology.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Santiago, Aleixo Li, Dawei Zhao, Lisa Y. Godsey, Adam Liao, Daiqing
spellingShingle	Santiago, Aleixo Li, Dawei Zhao, Lisa Y. Godsey, Adam Liao, Daiqing p53 SUMOylation promotes its nuclear export by facilitating its release from the nuclear export receptor CRM1
author_facet	Santiago, Aleixo Li, Dawei Zhao, Lisa Y. Godsey, Adam Liao, Daiqing
author_sort	Santiago, Aleixo
title	p53 SUMOylation promotes its nuclear export by facilitating its release from the nuclear export receptor CRM1
title_short	p53 SUMOylation promotes its nuclear export by facilitating its release from the nuclear export receptor CRM1
title_full	p53 SUMOylation promotes its nuclear export by facilitating its release from the nuclear export receptor CRM1
title_fullStr	p53 SUMOylation promotes its nuclear export by facilitating its release from the nuclear export receptor CRM1
title_full_unstemmed	p53 SUMOylation promotes its nuclear export by facilitating its release from the nuclear export receptor CRM1
title_sort	p53 sumoylation promotes its nuclear export by facilitating its release from the nuclear export receptor crm1
description	p53 SUMOylation promotes its nuclear export. The SIM-binding groove of a SUMO moiety linked to p53 and a SIM in CRM1 regulates their interaction. CRM1 binds to tetrameric p53 with a properly folded core domain, and CRM1 with a mutated SIM in the HEAT9 loop accumulates with SUMOylated p53 at NPCs and cytoplasmic aggregates.
publisher	The American Society for Cell Biology
publishDate	2013
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3756925/
_version_	1612006801978425344

p53 SUMOylation promotes its nuclear export by facilitating its release from the nuclear export receptor CRM1

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